Publication:
The estrogenic effect of Pueraria mirifica on gonadotrophin levels in aged monkeys

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Issued Date

2006

Resource Type

Article

File Type

application/pdf

ISSN

1355008X

DOI

10.1385/ENDO:29:1:129

Other identifier(s)

2-s2.0-33646861393

Rights Holder(s)

Scopus

Bibliographic Citation

Endocrine. Vol 29, No.1 (2006), p.129-134

Suggested Citation

Trisomboon H., Malaivijitnond S., Watanabe G., Cherdshewasart W., Taya K. The estrogenic effect of Pueraria mirifica on gonadotrophin levels in aged monkeys. Endocrine. Vol 29, No.1 (2006), p.129-134. doi:10.1385/ENDO:29:1:129 Retrieved from: https://hdl.handle.net/20.500.14740/5719

Title

The estrogenic effect of Pueraria mirifica on gonadotrophin levels in aged monkeys

Author(s)

Trisomboon H.
 Malaivijitnond S.
 Watanabe G.
 Cherdshewasart W.
 Taya K.

Abstract

We investigated the effect of Pueraria mirifica (PM) on gonadotrophin and estradiol levels in aged animals; nine menopausal cynomolgus monkeys were divided into three groups. Each group (n = 3) was fed with 10, 100, and 1000 mg/d of PM for 90 d. PM-10 induced the decrease of follicle stimulating hormone (FSH) levels on d 15-90 in one out of three monkeys. PM-100 and PM-1000 decreased FSH levels of all monkeys throughout the treatment period. After the treatment period, FSH levels continued to decrease for 5 and 10-20 d in PM-100 and PM-1000, respectively, and the levels rebounded in all groups thereafter. PM-10 decreased luteinizing hormone (LH) levels throughout the treatment period in one out of three monkeys and returned to the pretreatment levels immediately after stopping treatment. PM-100 and PM-1000 prominently decreased LH levels between d 10 and 90 during treatment and persisted until d 15-25 and d 20-30 for PM-100 and PM-1000, respectively, during the post-treatment period. Serum LH levels rebounded after returning to pre-treatment levels in a dose-dependent manner. Estradiol levels tended to decrease during the treatment period in all groups. The daily feeding of PM suppressed gonadotrophin levels in aged menopausal monkeys based on dose. Moreover, they can be recovered, and there is a direct correlation between dosage and recovery time. PM may be effective as an alternative medicine in menopausal women because the effects are not permanent. © 2006 by Humana Press Inc. All rights of any nature whatsoever reserved.

Subject(s)

Estradiol
 Follitropin
 Gonadotropin
 Herbaceous agent
 Luteinizing hormone
 Pueraria mirifica extract
 Unclassified drug
 Aged
 Animal experiment
 Article
 Dose response
 Estradiol blood level
 Female
 Follitropin blood level
 Gonadotropin blood level
 Luteinizing hormone blood level
 Menopause
 Monkey
 Nonhuman
 Priority journal
 Pueraria
 Pueraria mirifica
 Aging
 Animals
 Dose-Response Relationship, Drug
 Estradiol
 Female
 Follicle Stimulating Hormone
 Gonadotropins
 Luteinizing Hormone
 Macaca fascicularis
 Menopause
 Phytotherapy
 Plant Preparations
 Pueraria
 Radioimmunoassay

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URI

https://hdl.handle.net/20.500.14740/5719

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Scopus: Year 1983-2021

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