Publication:
Neuritogenic and neuroprotective activities of fruit residues

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Issued Date

2013

Resource Type

Article

File Type

application/pdf

ISSN

1934578X

DOI

10.1177/1934578x1300801121

Other identifier(s)

2-s2.0-84887453077

Rights Holder(s)

Scopus

Bibliographic Citation

Natural Product Communications. Vol 8, No.11 (2013), p.1583-1586

Suggested Citation

Tadtong S., Kanlayavattanakul M., Lourith N. Neuritogenic and neuroprotective activities of fruit residues. Natural Product Communications. Vol 8, No.11 (2013), p.1583-1586. doi:10.1177/1934578x1300801121 Retrieved from: https://hdl.handle.net/20.500.14740/6521

Title

Neuritogenic and neuroprotective activities of fruit residues

Author(s)

Tadtong S.
 Kanlayavattanakul M.
 Lourith N.

Abstract

Neuritogenic and neuroprotective activities of litchi (Litchi chinensis Sonn., Sapindaceae) and salacca (Salacca edulis Reinw., Arecaceae) pericarp, and sapodilla (Achras sapota L., Sapotaceae) and tamarind Srichompu cultivar (Tamarindus indica L., Caesalpiniaceae) seed coat extracts were evaluated on cultured cholinergic P19-derived neurons. All the extracts, at a very low concentration (1 ng/mL of litchi and salacca pericarp extracts, 10 ng/mL of sapodilla and 100 ng/mL of tamarind seed coat extracts), enhanced the survival of cultured neurons (% viability more than 100%) by XTT reduction assay. The extracts were further evaluated for their neuritogenicity by observing cell morphology by phase-contrast microscopy and neuroprotective activity in serum deprivation and pre- and co-administration of hydrogen peroxide models. The phase-contrast micrographs displayed that all of the extracts possessed neurogenic activity by promoting the neurite outgrowth of the cultured neurons. Moreover, these extracts can protect neurons from oxidative stress-caused cell death in a serum deprivation model, and prevent and protect neuron cells from the toxicity of hydrogen peroxide. In this study we assured that the neuritogenic and neuroprotective activities of these extracts derived from the phenolic components and flavonoids contained in the extracts by acting as signaling molecules to enhance neuron survival and promote neurite outgrowth. These results suggest that all of the extracts are potentially sources of neuritogenic and neuroprotective components which might be used either as pharmaceutical products or dietary supplements for neurodegenerative disorder patients, for example, those suffering from Alzheimer's disease.

Subject(s)

Achras sapota extract
 Flavonoid
 Hydrogen peroxide
 Litchi chinensis extract
 Neuroprotective agent
 Phenol derivative
 Plant extract
 Salacca edulis extract
 Tamarindus indica extract
 Unclassified drug
 Animal cell
 Article
 Cell death
 Cell structure
 Cell survival
 Cholinergic nerve cell
 Concentration response
 Controlled study
 Drug activity
 Drug cytotoxicity
 Embryo
 Fruit
 Lychee
 Mouse
 Nerve fiber growth
 Neuritogenic activity
 Neuroprotection
 Nonhuman
 Oxidative stress
 Pericarp
 Phase contrast microscopy
 Salacca edulis
 Sapodilla
 Seed husk
 Tamarind
 Arecaceae
 Caesalpinioideae
 Litchi chinensis
 Manilkara zapota
 Salacca
 Salacca edulis
 Sapindaceae
 Sapotaceae
 Tamarindus indica
 Animals
 Arecaceae
 Embryonal Carcinoma Stem Cells
 Fruit
 Litchi
 Mice
 Neurites
 Neuroprotective Agents
 Plant Extracts
 Sapindaceae

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URI

https://hdl.handle.net/20.500.14740/6521

Collections

Scopus: Year 1983-2021

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