Publication:
Prevalence and clinical manifestations of rotavirus diarrhea in children of rural area of Thailand

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Issued Date

2011

Resource Type

Article

File Type

application/pdf

ISSN

18404529

Other identifier(s)

2-s2.0-80052577160

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

International Journal of Collaborative Research on Internal Medicine and Public Health. Vol 3, No.9 (2011), p.695-702

Suggested Citation

Rerksuppaphol S., Rerksuppaphol L. Prevalence and clinical manifestations of rotavirus diarrhea in children of rural area of Thailand. International Journal of Collaborative Research on Internal Medicine and Public Health. Vol 3, No.9 (2011), p.695-702. Retrieved from: https://hdl.handle.net/20.500.14740/7246

Title

Prevalence and clinical manifestations of rotavirus diarrhea in children of rural area of Thailand

Author(s)

Rerksuppaphol S.
 Rerksuppaphol L.

Abstract

Introduction/ Background: Rotavirus diarrhoea is a leading cause of child death. It is a major concern in emerging nations. Many studies and analysis were executed for genetic assessment of rotavirus, however, very few studies from Thailand focused on clinical manifestation. Aim: To estimate the prevalence and clinical manifestations of rotavirus diarrhoea among children of Ongkaluck district, Nakorn Nayok rural area of Thailand. Method: Children aged ≤ 7 with acute diarrhoea as presenting symptom during January 2008 to October 2008 were enrolled in the study. Demographic data, clinical manifestation, vital parameters, laboratory investigation of blood, urine and stool were examined. Clinical signs of dehydration were graded as per WHO scale. Stool examination for rotavirus was tested with immunochromatography assay. Results: By executing statistical analysis, results were observed among 56 enrolled children 37 % (n=21) had been diagnosed as rotavirus positive. Rotavirus positive children had moderate to severe dehydration (42.9 % vs 11 %, p-value = 0.01), vomiting as presenting symptom (92.2 % vs 68.8 %, p-value = 0.02) and absence of fever (38.1 % vs 68.6 %, p-value= 0.03) compared to non-rotavirus group respectively. The odds ratio of being rotavirus diarrhoea was increased 10.8 fold (95% CI 1.2 to 97.4; p-value = 0.03) provided children had vomiting. Rotavirus positive children were prone to develop hypokalemia (pvalue=0.04), acidosis (p-value < 0.001), loss of bicarbonate (p-value < 0.001) and higher blood urea nitrogen (p-value = 0.02) than non-rotavirus group. Children with rotavirus diarrhoea had neutrophilia and less WBC in stool sample compared to Non-rotavirus acute diarrhoea group. Conclusion: Children admitted to the hospital, with moderate dehydration, absence of fever and vomiting as presenting symptoms are more prone to have rotavirus infection.

Subject(s)

Bicarbonate
 Nitrogen
 Urea
 Acidosis
 Acute diarrhea
 Article
 Blood analysis
 Child
 Clinical feature
 Dehydration
 Disease course
 Disease severity
 Feces analysis
 Human
 Human rotavirus
 Hypokalemia
 Immunoaffinity chromatography
 Leukocyte count
 Major clinical study
 Neutrophilia
 Nonhuman
 Patient assessment
 Preschool child
 Prevalence
 Rotavirus infection
 School child
 Thailand
 Urea nitrogen blood level
 Urinalysis
 Virus detection
 Vomiting

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URI

https://hdl.handle.net/20.500.14740/7246

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Scopus: Year 1983-2021

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