Publication:
Curcumin protects nigrostriatal dopaminergic neurons and reduces glial activation in 6-hydroxydopamine hemiparkinsonian mice model

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Issued Date

2012

Resource Type

Article

File Type

application/pdf

ISSN

207454

DOI

10.3109/00207454.2011.648760

Other identifier(s)

2-s2.0-84859395842

Rights Holder(s)

Scopus

Bibliographic Citation

International Journal of Neuroscience. Vol 122, No.5 (2012), p.263-270

Suggested Citation

Tripanichkul W., Jaroensuppaperch E.-O. Curcumin protects nigrostriatal dopaminergic neurons and reduces glial activation in 6-hydroxydopamine hemiparkinsonian mice model. International Journal of Neuroscience. Vol 122, No.5 (2012), p.263-270. doi:10.3109/00207454.2011.648760 Retrieved from: https://hdl.handle.net/20.500.14740/7067

Title

Curcumin protects nigrostriatal dopaminergic neurons and reduces glial activation in 6-hydroxydopamine hemiparkinsonian mice model

Author(s)

Tripanichkul W.
 Jaroensuppaperch E.-O.

Abstract

This study investigated the effects of curcumin on nigrostriatal dopaminergic (DA) neurons and glial response in 6-hydroxydopamine (6-OHDA) hemiparkinsonian mice. Following unilateral intrastriatal 6-OHDA injection, mice were daily injected with curcumin for seven days, beginning on the day of lesion. Seven days after 6-OHDA lesioning, sections from the striatum and the substantia nigra pars compacta (SNpc) were collected and immunohistochemically stained for DA neurons and reactive glia. Curcumin decreased 6-OHDA-induced loss of nigral tyrosine hydroxylase-immunoreactive (TH-IR) neurons and striatal TH-IR fibers. The neuroprotection was coincided with a significant attenuation of microglial and astroglial reaction in the SNpc and the striatum. These results suggest that the neuroprotective effects of curcumin in 6-OHDA-lesioned mice may be mediated through its anti-inflammatory properties or direct protection on nigral DA neurons, thereby reducing neuronal injury-induced glial activation. © 2011 Informa Healthcare USA, Inc.

Subject(s)

Curcumin
 Oxidopamine
 Tyrosine 3 monooxygenase
 Animal experiment
 Animal model
 Animal tissue
 Article
 Controlled study
 Corpus striatum
 Dopaminergic nerve cell
 Glia
 Immunohistochemistry
 Immunoreactivity
 Macroglia
 Male
 Mouse
 Neuroprotection
 Nigroneostriatal system
 Nonhuman
 Parkinsonism
 Substantia nigra
 Animals
 Corpus Striatum
 Curcumin
 Disease Models, Animal
 Dopaminergic Neurons
 Male
 Mice
 Mice, Inbred ICR
 Neural Pathways
 Neuroglia
 Parkinsonian Disorders
 Substantia Nigra
 Treatment Outcome

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URI

https://hdl.handle.net/20.500.14740/7067

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Scopus: Year 1983-2021

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