Publication:
Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: A randomized controlled trial

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Issued Date

2014

Resource Type

Article

File Type

application/pdf

ISSN

9552863

DOI

10.1016/j.jnutbio.2013.09.013

Other identifier(s)

2-s2.0-84892527914

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Nutritional Biochemistry. Vol 25, No.2 (2014), p.144-150

Suggested Citation

Chuengsamarn S., Rattanamongkolgul S., Phonrat B., Tungtrongchitr R., Jirawatnotai S. Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: A randomized controlled trial. Journal of Nutritional Biochemistry. Vol 25, No.2 (2014), p.144-150. doi:10.1016/j.jnutbio.2013.09.013 Retrieved from: https://hdl.handle.net/20.500.14740/7107

Title

Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: A randomized controlled trial

Author(s)

Chuengsamarn S.
 Rattanamongkolgul S.
 Phonrat B.
 Tungtrongchitr R.
 Jirawatnotai S.

Abstract

Curcumin is a phytocompound found in the root of turmeric, a common herbal ingredient in many Asian cuisines. The compound contains anti-inflammatory activity, which is mediated through an up-regulation of adiponectin and reduction of leptin. Consumption of curcumin was shown to prevent some deteriorative conditions caused by inflammation, such as ulcerative colitis, rheumatoid arthritis and esophagitis, and so on. Inflammation-associated cardiovascular conditions such as atherosclerosis are common in diabetes patients. The anti-inflammation effect of curcumin might be beneficial to prevent such condition in these patients. We aim to evaluate an antiatherosclerosis effect of curcumin in diabetes patients. Effects of curcumin on risk factors for atherosclerosis were investigated in a 6-month randomized, double-blinded and placebo-controlled clinical trial that included subjects diagnosed with type 2 diabetes. An atherosclerosis parameter, the pulse wave velocity, and other metabolic parameters in patients treated with placebo and curcumin were compared. Our results showed that curcumin intervention significantly reduced pulse wave velocity, increased level of serum adiponectin and decreased level of leptin. These results are associated with reduced levels of homeostasis model assessment-insulin resistance, triglyceride, uric acid, visceral fat and total body fat. In summary, a 6-month curcumin intervention in type 2 diabetic population lowered the atherogenic risks. In addition, the extract helped to improve relevant metabolic profiles in this high-risk population. © 2014 Elsevier Inc.

Subject(s)

Adiponectin
 Alanine aminotransferase
 Curcumin
 Glucose
 Hemoglobin A1c
 High density lipoprotein cholesterol
 Leptin
 Low density lipoprotein cholesterol
 Triacylglycerol
 Uric acid
 Abdominal obesity
 Adult
 Article
 Atherosclerosis
 Body fat
 Body mass
 Body weight
 Cardiovascular risk
 Cholesterol blood level
 Comparative study
 Constipation
 Controlled study
 Diabetic patient
 Double blind procedure
 Drug efficacy
 Drug safety
 Fasting plasma glucose
 Female
 Follow up
 Glucose blood level
 Hot flush
 Human
 Insulin resistance
 Intraabdominal fat
 Major clinical study
 Male
 Metabolic parameters
 Middle aged
 Nausea
 Non insulin dependent diabetes mellitus
 Parallel design
 Protein blood level
 Pruritus
 Pulse wave
 Randomized controlled trial
 Vertigo
 Waist circumference
 Abdominal obesity (visceral fat and total body fat)
 Atherogenic risk
 Curcuminoid extract
 Insulin resistance
 Pulse wave velocity (PWV)
 Type 2 diabetes
 Atherosclerosis
 Curcumin
 Diabetes Mellitus, Type 2
 Double-Blind Method
 Female
 Humans
 Male
 Middle Aged
 Patient Compliance
 Placebos

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URI

https://hdl.handle.net/20.500.14740/7107

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Scopus: Year 1983-2021

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