Publication: Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid
0
0
Issued Date
2012
Resource Type
File Type
application/pdf
ISSN
8895406
Other identifier(s)
2-s2.0-84860485575
Rights Holder(s)
Scopus
Bibliographic Citation
American Journal of Orthodontics and Dentofacial Orthopedics. Vol 141, No.5 (2012), p.563-573
Suggested Citation
Sirisoontorn I., Hotokezaka H., Hashimoto M., Gonzales C., Luppanapornlarp S., Darendeliler M.A., Yoshida N. Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid. American Journal of Orthodontics and Dentofacial Orthopedics. Vol 141, No.5 (2012), p.563-573. doi:10.1016/j.ajodo.2011.11.016 Retrieved from: https://hdl.handle.net/20.500.14740/7073
Abstract
Introduction: The effect of zoledronic acid, a potent and novel bisphosphonate, on tooth movement and orthodontically induced root resorption in osteoporotic animals systemically treated with zoledronic acid as similarly used in postmenopausal patients has not been elucidated. Therefore, this study was undertaken. Methods: Fifteen 10-week-old female Wistar rats were divided into 3 groups: ovariectomy, ovariectomy + zoledronic acid, and control. Only the ovariectomy and ovariectomy + zoledronic acid groups underwent ovariectomies. Two weeks after the ovariectomy, zoledronic acid was administered only to the ovariectomy + zoledronic acid group. Four weeks after the ovariectomy, 25-g nickel-titanium closed-coil springs were applied to observe tooth movement and orthodontically induced root resorption. Results: There were significant differences in the amounts of tooth movement and orthodontically induced root resorption between the ovariectomy and the control groups, and also between the ovariectomy and the ovariectomy + zoledronic acid groups. There was no statistically significant difference in tooth movement and orthodontically induced root resorption between the ovariectomy + zoledronic acid and the control groups. Zoledronic acid inhibited significantly more tooth movement and significantly reduced the severity of orthodontically induced root resorption in the ovariectomized rats. The ovariectomy + zoledronic acid group showed almost the same results as did the control group in both tooth movement and orthodontically induced root resorption. Conclusions: Zoledronic acid inhibits excessive orthodontic tooth movement and also reduces the risk of severe orthodontically induced root resorption in ovariectomized rats. Copyright © 2012 by the American Association of Orthodontists.
Subject(s)
Bisphosphonic acid derivative
Bone density conservation agent
Imidazole derivative
Zoledronic acid
Animal
Article
Comparative study
Disease model
Female
Osteoporosis
Periodontal disease
Postmenopause
Rat
Tooth disease
Wistar rat
Animals
Bone Density Conservation Agents
Diphosphonates
Disease Models, Animal
Female
Imidazoles
Osteoporosis
Postmenopause
Rats
Rats, Wistar
Root Resorption
Tooth Movement
Bone density conservation agent
Imidazole derivative
Zoledronic acid
Animal
Article
Comparative study
Disease model
Female
Osteoporosis
Periodontal disease
Postmenopause
Rat
Tooth disease
Wistar rat
Animals
Bone Density Conservation Agents
Diphosphonates
Disease Models, Animal
Female
Imidazoles
Osteoporosis
Postmenopause
Rats
Rats, Wistar
Root Resorption
Tooth Movement