Publication: Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac
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Issued Date
2012
Resource Type
File Type
application/pdf
ISSN
1633864
Other identifier(s)
2-s2.0-84870167887
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Journal of Natural Products. Vol 75, No.11 (2012), p.1999-2002
Suggested Citation
Awale S., Ueda J.-Y., Athikomkulchai S., Dibwe D.F., Abdelhamed S., Yokoyama S., Saiki I., Miyatake R. Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac. Journal of Natural Products. Vol 75, No.11 (2012), p.1999-2002. doi:10.1021/np300596c Retrieved from: https://hdl.handle.net/20.500.14740/6918
Abstract
Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circular dichroism spectroscopic analysis. Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions. © 2012 The American Chemical Society and American Society of Pharmacognosy.