Publication:
The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: A pilot study

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Issued Date

2015

Resource Type

Article

File Type

application/pdf

ISSN

195154

DOI

10.4103/0019-5154.147838

Other identifier(s)

2-s2.0-84920469459

Rights Holder(s)

Scopus

Bibliographic Citation

Indian Journal of Dermatology. Vol 60, No.1 (2015), p.103-

Suggested Citation

Treesirichod A., Chaithirayanon S., Wongjitrat N., Wattanapan P. The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: A pilot study. Indian Journal of Dermatology. Vol 60, No.1 (2015), p.103-. doi:10.4103/0019-5154.147838 Retrieved from: https://hdl.handle.net/20.500.14740/6242

Title

The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: A pilot study

Author(s)

Treesirichod A.
 Chaithirayanon S.
 Wongjitrat N.
 Wattanapan P.

Abstract

Aims: To assess the degree of improvement of neck hyperpigmentation in childhood acanthosis nigricans (AN) after treatment with topical 0.1% adapalene gel and the assessment of localized tissue tolerance to the gel. Subjects and Methods: A split comparison study of the hyperpigmentation on the neck was conducted in patients diagnosed with childhood AN. Patients were treated with topical 0.1% adapalene gel for a period of 4 weeks. The skin color of their neck was evaluated at baseline, 2 weeks and 4 weeks using a skin color chart. Skin color ratio (the skin on their necks compared with the skin on their backs) was calculated for all subjects. The investigator's global evaluation (IGE) scale and the parent's global evaluation (PGE) scale were used to assess the efficacy of the patients' treatment at the end of the 4th week. Results: The mean skin color ratio of therapeutic side was significantly decreased from the baseline scores, at weeks 2 and 4, respectively (30.1%, 18.3%, and 12.9%, P < 0.001), with marked skin improvement at 60.7% ± 28.5%. The percentage of changes of skin color ratio was consistent with the efficacy evaluations as performed by the IGE and PGE scales. Treatment-related cutaneous irritation was minimal, predominantly in the first 2 weeks of treatment and was shown to be well-tolerated at week 4 following a modification of the treatment regimen. Conclusions: The study has shown the efficacy of topical 0.1% adapalene gel in the treatment of AN, specifically, in regards to the skin darkening with minimal cutaneous irritation. © 2015 Indian Journal of Dermatology.

Subject(s)

Adapalene
 Placebo
 Acanthosis nigricans
 Adolescent
 Application site burning
 Application site dryness
 Application site erythema
 Application site irritation
 Application site pruritus
 Article
 Body mass
 Childhood disease
 Clinical article
 Clinical evaluation
 Comparative effectiveness
 Controlled clinical trial
 Controlled study
 Disease predisposition
 Drug efficacy
 Drug tolerability
 Drug use
 Dry skin
 Female
 Gel
 Human
 Hyperpigmentation
 Male
 Neck
 Obesity
 Pilot study
 Rating scale
 Skin abrasion
 Skin burning sensation
 Skin color
 Skin irritation
 Skin pruritus
 Topical treatment
 Treatment duration
 Weight change

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URI

https://hdl.handle.net/20.500.14740/6242

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Scopus: Year 1983-2021

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