Publication: Dengue hemorrhagic fever and the liver
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Issued Date
2021
Resource Type
Language
eng
File Type
application/pdf
ISSN
19485182
Other identifier(s)
2-s2.0-85123896382
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
World Journal of Hepatology. Vol 13, No.12 (2021), p.1968-1976
Suggested Citation
Leowattana W., Leowattana T. Dengue hemorrhagic fever and the liver. World Journal of Hepatology. Vol 13, No.12 (2021), p.1968-1976. doi:10.4254/wjh.v13.i12.1968 Retrieved from: https://hdl.handle.net/20.500.14740/7913
Author(s)
Abstract
Dengue hemorrhagic fever (DHF) is one of the most rapidly emerging infections of tropical and subtropical regions worldwide. It affects more rural and urban areas due to many factors, including climate change. Although most people with dengue viral infection are asymptomatic, approximately 25% experience a selflimited febrile illness with mild to moderate biochemical abnormalities. Severe dengue diseases develop in a small proportion of these patients, and the common organ involvement is the liver. The hepatocellular injury was found in 60%-90% of DHF patients manifested as hepatomegaly, jaundice, elevated aminotransferase enzymes, and critical condition as an acute liver failure (ALF). Even the incidence of ALF in DHF is very low (0.31%-1.1%), but it is associated with a relatively high mortality rate (20%-68.3%). The pathophysiology of liver injury in DHF included the direct cytopathic effect of the DENV causing hepatocytes apoptosis, immune-mediated hepatocyte injury induced hepatitis, and cytokine storm. Hepatic hypoperfusion is another contributing factor in dengue shock syndrome. The reduction of morbidity and mortality in DHF with liver involvement is dependent on the early detection of warning signs before the development of ALF. © 2021 The Author(s). Published by Baishideng Publishing Group Inc. All Rights Reserved.