Publication:
Protection against cisplatin-induced nephrotoxicity in mice by Curcuma comosa Roxb. ethanol extract

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Issued Date

2009

Resource Type

Article

File Type

application/pdf

ISSN

13403443

DOI

10.1007/s11418-009-0345-5

Other identifier(s)

2-s2.0-69949132511

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Natural Medicines. Vol 63, No.4 (2009), p.430-436

Suggested Citation

Jariyawat S., Kigpituck P., Suksen K., Chuncharunee A., Chaovanalikit A., Piyachaturawat P. Protection against cisplatin-induced nephrotoxicity in mice by Curcuma comosa Roxb. ethanol extract. Journal of Natural Medicines. Vol 63, No.4 (2009), p.430-436. doi:10.1007/s11418-009-0345-5 Retrieved from: https://hdl.handle.net/20.500.14740/4251

Title

Protection against cisplatin-induced nephrotoxicity in mice by Curcuma comosa Roxb. ethanol extract

Author(s)

Jariyawat S.
 Kigpituck P.
 Suksen K.
 Chuncharunee A.
 Chaovanalikit A.
 Piyachaturawat P.

Abstract

The protective effect of an ethanol extract of Curcuma comosa against cisplatin-induced renal toxicity in mice was studied. Adult male mice were pretreated for 4 days with the ethanol extract of C. comosa [100-200 mg/kg body weight (BW), orally (p.o.)] before injection of cisplatin (12.5 mg/kg BW, intraperitoneally (i.p.)). Five days later the mice were killed, and blood samples were collected to determine blood urea nitrogen (BUN) and plasma creatinine levels. Kidneys were examined histopathologically and levels of lipid peroxidation, gluthathione (GSH) content, and superoxide dismutase (SOD), gluthathione peroxidase (GPx), and catalase (CAT) activities were determined. Histological examinations revealed degenerative changes and tubular necrosis in mice treated with cisplatin, which were improved by pretreatment with C. comosa ethanol extract. Cisplatin raised BUN, creatinine, and kidney lipid peroxidation levels, and lowered kidney GSH content and levels of GPx, SOD, and CAT activities, all of which (except SOD and CAT) could be restored to normal values by pretreatment with 200 mg/kg BW of C. comosa ethanol extract. In addition, the ethanol extract of C. comosa and its isolated diarylheptanoid compound also exhibited radical scavenging activities. The results suggest that the ethanol extract of C. comosa exhibits effective protection against cisplatin-induced nephrotoxicity mediated through its antioxidant activity. © 2009 The Japanese Society of Pharmacognosy and Springer.

Subject(s)

Alcohol
 Antioxidant
 Ascorbic acid
 Catalase
 Cisplatin
 Creatinine
 Curcuma comosa extract
 Glutathione
 Glutathione peroxidase
 Plant extract
 Scavenger
 Superoxide dismutase
 Trolox C
 Unclassified drug
 Animal experiment
 Animal tissue
 Antioxidant activity
 Article
 Blood sampling
 Controlled study
 Creatinine blood level
 Curcuma comosa
 Degeneration
 Drug structure
 Histopathology
 Kidney tubule necrosis
 Lipid peroxidation
 Male
 Medicinal plant
 Mouse
 Nephrotoxicity
 Nonhuman
 Urea nitrogen blood level
 Animals
 Antioxidants
 Catalase
 Cisplatin
 Curcuma
 Ethanol
 Glutathione
 Glutathione Peroxidase
 Kidney
 Male
 Mice
 Molecular Structure
 Plant Extracts
 Superoxide Dismutase

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URI

https://hdl.handle.net/20.500.14740/4251

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Scopus: Year 1983-2021

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