Publication:
A comparative study on the effectiveness of herbal extracts vs 2.5% benzoyl peroxide in the treatment of mild to moderate acne vulgaris

2
0

Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

14732130

DOI

10.1111/jocd.12962

Other identifier(s)

2-s2.0-85064699360

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of Cosmetic Dermatology. Vol 18, No.6 (2019), p.1767-1775

Suggested Citation

Lubtikulthum P., Kamanamool N., Udompataikul M. A comparative study on the effectiveness of herbal extracts vs 2.5% benzoyl peroxide in the treatment of mild to moderate acne vulgaris. Journal of Cosmetic Dermatology. Vol 18, No.6 (2019), p.1767-1775. doi:10.1111/jocd.12962 Retrieved from: https://hdl.handle.net/20.500.14740/5045

Title

A comparative study on the effectiveness of herbal extracts vs 2.5% benzoyl peroxide in the treatment of mild to moderate acne vulgaris

Author(s)

Lubtikulthum P.
 Kamanamool N.
 Udompataikul M.

Abstract

Background: Although there is a standard guideline for the treatment of acne, it is still a common skin disease, and suboptimal medication adherence is a major reason for treatment failure. Herbal extracts are an interesting alternative medicine because they consist of a variety of active ingredients. Moreover, herbal extracts may have improved therapeutic efficacy because of the combination of various herbs. Objectives: To evaluate the effectiveness of herbal extracts for the treatment of mild to moderate acne vulgaris. Methods: A total of 77 patients were randomized to receive either an herbal extract or 2.5% benzoyl peroxide, which were applied for a period of 12 weeks. Acne lesion counts, adherence, porphyrin counts, the Dermatology Life Quality Index, satisfaction and side effects were assessed. Result: At the 12-week point, the acne lesion counts decreased, with statistically significant differences from the baseline values in both groups and for all types of acne (P-value < 0.001). The adherence rate was significantly higher in the patients using the herbal extract than in the patients using 2.5% benzoyl peroxide (P-value = 0.002). There was no statistically significant difference in terms of porphyrin counts, spot scores, the Dermatology Life Quality Index or satisfaction with efficacy between the groups; however, satisfaction with drug administration was significantly higher in the patients using the herbal extract (P-value = 0.001). Conclusion: Herbal extracts could be beneficial for anti-acne pharmaceutical preparations and may be used as an alternative medicine for patients with mild to moderate acne vulgaris who do not adhere to benzoyl peroxide treatment. © 2019 Wiley Periodicals, Inc.

Subject(s)

Benzoyl peroxide
 Herbaceous agent
 Porphyrin
 Scagel acne spot
 Benzoyl peroxide
 Dermatological agent
 Plant extract
 Acne vulgaris
 Adult
 Article
 Burning sensation
 Comparative study
 Controlled study
 Dermatology Life Quality Index
 Drug efficacy
 Drug safety
 Erythema
 Female
 Human
 Major clinical study
 Male
 Medication compliance
 Papular rash
 Patient compliance
 Patient satisfaction
 Priority journal
 Pruritus
 Randomized controlled trial
 Skin edema
 Skin irritation
 Treatment outcome
 Acne vulgaris
 Psychology
 Quality of life
 Severity of illness index
 Young adult
 Acne Vulgaris
 Benzoyl Peroxide
 Dermatologic Agents
 Female
 Humans
 Male
 Medication Adherence
 Patient Satisfaction
 Plant Extracts
 Quality of Life
 Severity of Illness Index
 Treatment Outcome
 Young Adult

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URI

https://hdl.handle.net/20.500.14740/5045

Collections

Scopus: Year 1983-2021

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