Publication: Lipid-lowering and antioxidant properties of probiotic Bifidobacterium animalis MSMC83 in rats on a high-fat diet
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Issued Date
2025-01-01
Resource Type
ISSN
18762883
eISSN
18762891
Scopus ID
2-s2.0-85207790873
Pubmed ID
39414243
Journal Title
Beneficial Microbes
Volume
16
Issue
2
Start Page
237
End Page
252
Rights Holder(s)
SCOPUS
Bibliographic Citation
Beneficial Microbes Vol.16 No.2 (2025) , 237-252
Suggested Citation
Chantarangkul C., Phuengmaung P., Leelahavanichkul A., Piewngam P., Otto M., Taweechotipatr M. Lipid-lowering and antioxidant properties of probiotic Bifidobacterium animalis MSMC83 in rats on a high-fat diet. Beneficial Microbes Vol.16 No.2 (2025) , 237-252. 252. doi:10.1163/18762891-bja00043 Retrieved from: https://hdl.handle.net/20.500.14740/20373
Corresponding Author(s)
Other Contributor(s)
Abstract
Hyperlipidaemia, the abnormally high concentration of lipids such as cholesterol in the body, has a series of deleterious effects on health that are least in part are due to increased inflammation and oxidative stress. Probiotics are living microorganisms that possess the efficacy to improve health. Among the many effects that have been ascribed to probiotics is the potential to lower the body lipid content. Here, we used a rat model of induced hyperlipidaemia to assess the lipid-lowering and antioxidant properties of the probiotic strain Bifidobacterium animalis MSMC83 as well as its impact on intestinal barrier immunity and the intestinal microbiota. Oral probiotic intake led to a reduction of body weight, fasting blood glucose, and lipid levels, and increased expression of cholesterol-7α-hydroxylase and antioxidant enzymes. Additionally, B. animalis MSMC83 decreased the levels of liver enzymes and pro-inflammatory cytokines, leading to reduced hepatic steatosis. Furthermore, it re-established intestinal barrier integrity as shown by restoration of the tight junction protein zonula occludens-1 amount and reduced pathogen-induced inflammation in the intestinal epithelium as shown by readjusted expression of toll-like receptors (TLRs). Moreover B. animalis MSMC83 contributed to the maintenance of a balanced, diverse microbiome. Thus, our results indicate that B. animalis MSMC83 alleviates risk factors associated with hyperlipidaemia, suggesting its use as a probiotic to counter the effects associated with unhealthy diets.