Publication: Mesenchymal stem cells for restoring endometrial function: An infertility perspective
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Issued Date
2021
Resource Type
File Type
application/pdf
ISSN
14455781
Other identifier(s)
2-s2.0-85088582626
Rights
Srinakharinwirot University
Rights Holder(s)
Scopus
Bibliographic Citation
Reproductive Medicine and Biology. Vol 20, No.1 (2021), p.13-19
Suggested Citation
Rungsiwiwut R., Virutamasen P., Pruksananonda K. Mesenchymal stem cells for restoring endometrial function: An infertility perspective. Reproductive Medicine and Biology. Vol 20, No.1 (2021), p.13-19. doi:10.1002/rmb2.12339 Retrieved from: https://hdl.handle.net/20.500.14740/5086
Author(s)
Abstract
Background: Mesenchymal stem cells (MSCs) can be derived from several tissues such as bone marrow, placenta, adipose tissue, or endometrial tissue. MSCs gain a lot of attention for cell-based therapy due to their characteristics including differentiation ability and immunomodulatory effect. Preclinical and clinical studies demonstrated that MSCs can be applied to treat female infertility by improving of the functions of ovary and uterus. This mini- review focuses on the current study of treatment of endometrial infertility by using MSCs. Methods: The present study performed a literature review focusing on the effect of MSCs for treatment of women infertility caused by endometrial dysfunction. Results: Bone marrow-, umbilical cord-, adipose-, amniotic-, and menstruation-derived MSCs enhance endometrial cell proliferation, injury repairs as well as reducing scar formation. The beneficial mechanism probably via immunomodulatory, cell differentiation, stimulates endometrial cell proliferation and down-regulation of fibrosis genes. The major advantage of using MSCs is to improve endometrial functions resulting in increased implantation and pregnancy. Conclusions: MSCs exhibit a potential for endometrial infertility treatment. Adipose- and menstruation-derived stem cells show advantages over other sources because the cells can be derived easily and do not causes graft rejection after autologous transplantation. © 2020 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.