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Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus

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dc.contributor.authorYingyongnarongkul B.-E.
dc.contributor.authorApiratikul N.
dc.contributor.authorAroonrerk N.
dc.contributor.authorSuksamrarn A.
dc.date.accessioned2021-04-05T04:32:17Z
dc.date.available2021-04-05T04:32:17Z
dc.date.issued2006
dc.date.issuedBE2549
dc.description.abstractA library of hydroxycinnamic acid amides (HCAAs) and analogues were synthesized using solid-phase synthesis technique. These compounds were screened for antibacterial against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-resistant S. aureus (VRSA) (4 strains). Dihydrocaffeoyl analogues showed activity against VRSA which were better than the reference drugs, vancomycin and oxacillin. These compounds also exhibited antibacterial activity against MRSA, which were more potent than oxacillin. © 2006 Elsevier Ltd. All rights reserved.
dc.format.mimetypeapplication/pdf
dc.identifier.citationBioorganic and Medicinal Chemistry Letters. Vol 16, No.22 (2006), p.5870-5873
dc.identifier.doi10.1016/j.bmcl.2006.08.062
dc.identifier.issn0960894X
dc.identifier.other2-s2.0-33749434812
dc.identifier.urihttps://hdl.handle.net/20.500.14740/5309
dc.rights.holderScopus
dc.subject.otherHydrocinnamic acid derivative
dc.subject.otherMeticillin
dc.subject.otherOxacillin
dc.subject.otherVancomycin
dc.subject.otherAntibacterial activity
dc.subject.otherAntibiotic resistance
dc.subject.otherArticle
dc.subject.otherBacterial strain
dc.subject.otherControlled study
dc.subject.otherDrug potency
dc.subject.otherDrug screening
dc.subject.otherDrug synthesis
dc.subject.otherMethicillin resistant Staphylococcus aureus
dc.subject.otherMinimum inhibitory concentration
dc.subject.otherNonhuman
dc.subject.otherSolid phase synthesis
dc.subject.otherStaphylococcus aureus
dc.subject.otherAmides
dc.subject.otherAnti-Bacterial Agents
dc.subject.otherCaffeine
dc.subject.otherCombinatorial Chemistry Techniques
dc.subject.otherCoumaric Acids
dc.subject.otherDrug Combinations
dc.subject.otherEthanol
dc.subject.otherMethicillin Resistance
dc.subject.otherOxacillin
dc.subject.otherStaphylococcus aureus
dc.subject.otherVancomycin Resistance
dc.subject.otherMethicillin resistant Staphylococcus aureus
dc.subject.otherStaphylococcus aureus
dc.titleSolid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33749434812&doi=10.1016%2fj.bmcl.2006.08.062&partnerID=40&md5=39c9287b3f1fcba02da89c016669696b

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