Publication:
Secondary metabolites from the marine-derived fungus dichotomomyces sp. L-8 and their cytotoxic activity

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Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

14203049

DOI

10.3390/molecules22030444

Other identifier(s)

2-s2.0-85015695560

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Molecules. Vol 22, No.3 (2017)

Suggested Citation

Huang L.-H., Chen Y.-X., Yu J.-C., Yuan J., Li H.-J., Ma W.-Z., Watanapokasin R., Hu K.-C., Niaz S.I., Yang D.-P., Lan W.-J. Secondary metabolites from the marine-derived fungus dichotomomyces sp. L-8 and their cytotoxic activity. Molecules. Vol 22, No.3 (2017). doi:10.3390/molecules22030444 Retrieved from: https://hdl.handle.net/20.500.14740/4237

Title

Secondary metabolites from the marine-derived fungus dichotomomyces sp. L-8 and their cytotoxic activity

Author(s)

Huang L.-H.
 Chen Y.-X.
 Yu J.-C.
 Yuan J.
 Li H.-J.
 Ma W.-Z.
 Watanapokasin R.
 Hu K.-C.
 Niaz S.I.
 Yang D.-P.
 Lan W.-J.

Abstract

Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including dichotocejpin C (3), bis-N-norgliovictin (4), bassiatin (5) and (3R,6R)-bassiatin (6). The structures of these compounds were determined by 1D, 2D NMR and mass spectrometry. (3R,6R)-bassiatin (6) displayed significant cytotoxic activities against the human breast cancer cell line MDA-MB-435 and the human lung cancer cell line Calu3 with IC50 values of 7.34 ± 0.20 and 14.54 ± 0.01 μM, respectively, while bassiatin (5), the diastereomer of compound 6, was not cytotoxic. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.

Subject(s)

Antineoplastic agent
 Bis-N-norgliovictin
 Lateritin
 Morpholine derivative
 Piperazinedione
 Sulfide
 Aquatic species
 Budding yeast
 Cell survival
 Chemical structure
 Chemistry
 Drug effects
 Human
 IC50
 Isolation and purification
 Metabolism
 Nuclear magnetic resonance spectroscopy
 Physiology
 Secondary metabolism
 Structure activity relation
 Tumor cell line
 Antineoplastic Agents, Phytogenic
 Aquatic Organisms
 Cell Line, Tumor
 Cell Survival
 Diketopiperazines
 Humans
 Inhibitory Concentration 50
 Magnetic Resonance Spectroscopy
 Molecular Structure
 Morpholines
 Saccharomycetales
 Secondary Metabolism
 Structure-Activity Relationship
 Sulfides

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URI

https://hdl.handle.net/20.500.14740/4237

Collections

Scopus: Year 1983-2021

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