Publication:
A herbal medicine used in the treatment of addiction mimics the action of amphetamine on in vitro rat striatal dopamine release

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Issued Date

2002

Resource Type

Article

File Type

application/pdf

ISSN

3043940

DOI

10.1016/S0304-3940(02)00658-4

Other identifier(s)

2-s2.0-0037199652

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Neuroscience Letters. Vol 329, No.2 (2002), p.129-132

Suggested Citation

Thongsaard W., Marsden C.A. A herbal medicine used in the treatment of addiction mimics the action of amphetamine on in vitro rat striatal dopamine release. Neuroscience Letters. Vol 329, No.2 (2002), p.129-132. doi:10.1016/S0304-3940(02)00658-4 Retrieved from: https://hdl.handle.net/20.500.14740/6709

Title

A herbal medicine used in the treatment of addiction mimics the action of amphetamine on in vitro rat striatal dopamine release

Author(s)

Thongsaard W.
 Marsden C.A.

Abstract

Thunbergia laurifolia Linn. (TH) and Simplocos racemosa Roxb. (SY) are herbal medicines used in the treatment of drug addiction without scientific support for their mechanism of action. The present study investigated the effects of these medicinal plants on dopaminergic neurotransmission in comparison with amphetamine. The effect of crude water extracts (0.1 g/ml) of TH and SY on K+ (20 mM)-stimulated dopamine release from rat striatal slices were compared with amphetamine (10-4 M) using high-performance liquid chromatography with electrochemical detection to measure endogenous dopamine. Amphetamine and TH, but not SY, significantly increased K+-stimulated dopamine release (P<0.001) from rat striatal slices when compared with K+-stimulated alone. TH potentiated the effect of amphetamine on K+-stimulated dopamine release (P<0.001) when compared with amphetamine alone. The results indicate that TH may stimulate dopamine release in the same manner as amphetamine. It remains to be determined whether the effect of these extracts on dopamine function is important in their therapeutic use in the treatment of drug addiction. © 2002 Published by Elsevier Science Ireland Ltd.

Subject(s)

Amphetamine
 Dopamine
 Plant extract
 Potassium ion
 Simplocos racemosa extract
 Thunbergia laurifolia extract
 Unclassified drug
 Amphetamine
 Dopamine
 Plant extract
 Plant medicinal product
 Addiction
 Animal tissue
 Article
 Brain slice
 Controlled study
 Corpus striatum
 Dopamine release
 Drug effect
 Drug mechanism
 Drug potency
 Electrochemical detection
 Herbal medicine
 High performance liquid chromatography
 In vitro study
 Male
 Neurotransmission
 Nonhuman
 Priority journal
 Rat
 Addiction
 Animal
 Biosynthesis
 Chemistry
 Comparative study
 Isolation and purification
 Metabolism
 Methodology
 Phytotherapy
 Plant leaf
 Secretion
 Wistar rat
 Amphetamine
 Animal
 Comparative Study
 Corpus Striatum
 Dopamine
 Male
 Phytotherapy
 Plant Extracts
 Plant Leaves
 Plant Preparations
 Rats
 Rats, Wistar
 Substance-Related Disorders
 Support, Non-U.S. Gov't
 Animals
 Male
 Plant Extracts
 Plant Leaves
 Rats
 Rats, Wistar

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URI

https://hdl.handle.net/20.500.14740/6709

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Scopus: Year 1983-2021

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