Publication:
A case report on the probable herb-drug interaction between stevia products and etoricoxib relating to declined kidney function

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-85070519773

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 102, No.7 (2019), p.100-104

Suggested Citation

Tangkiatkumjai M., Janma J., Changsirikulchai S. A case report on the probable herb-drug interaction between stevia products and etoricoxib relating to declined kidney function. Journal of the Medical Association of Thailand. Vol 102, No.7 (2019), p.100-104. Retrieved from: https://hdl.handle.net/20.500.14740/5214

Title

A case report on the probable herb-drug interaction between stevia products and etoricoxib relating to declined kidney function

Author(s)

Tangkiatkumjai M.
 Janma J.
 Changsirikulchai S.

Abstract

Stevia rebaudiana or its metabolites, steviol glycosides, has been used as a sweetener and has shown diuretic effects with excretion of sodium in long-term use. There is no report on nephropathy related to Stevia. The aim of the present study is to report a probable herb-drug interaction between Stevia and etoricoxib that may lead to acute kidney injury (AKI). A 47-year-old Thai woman reported that she took Stevia daily with etoricoxib 90 mg, 2 to 3 times a week for 6 months, and subsequently developed AKI. Her serum creatinine showed a significant increase. She had euthyroid and did not take any medications during that period. After the patient discontinued Stevia and etoricoxib, her serum creatinine returned to normal. A probable herb-drug interaction between Stevia products and etoricoxib was likely to be associated with prerenal AKI. The authors postulated an interaction with each other’s hemodynamic effects. A causal relationship between AKI and Stevia was assessed by the modified Naranjo algorithm. This algorithm indicated a probable relationship (5 scores) for Stevia. In summary, this is the first case report for humans relating to a probable herb-drug interaction between Stevia and etoricoxib associated with AKI. To prevent AKI, people who would like to use Stevia should be advised to drink large amounts of water and avoid using Stevia with NSAIDs or COX-2 inhibitors. © JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND| 2019.

Subject(s)

Creatinine
 Cyclooxygenase 2 inhibitor
 Etoricoxib
 Nonsteroid antiinflammatory agent
 Plant extract
 Stevia rebaudiana extract
 Thiamazole
 Unclassified drug
 Acute kidney failure
 Adult
 Algorithm
 Article
 Case report
 Clinical article
 Creatinine blood level
 Dizziness
 Drug withdrawal
 Fatigue
 Female
 Glomerulus filtration
 Glucose blood level
 Goiter
 Hemodynamics
 Herb drug interaction
 Human
 Hyperkalemia
 Hyponatremia
 Kidney function
 Kidney tubule disorder
 Middle aged
 Mouth mucosa
 Potassium blood level
 Prescription
 Questionnaire
 Sodium blood level
 Stevia rebaudiana
 Thyrotoxicosis

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URI

https://hdl.handle.net/20.500.14740/5214

Collections

Scopus: Year 1983-2021

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