Publication:
Copper complexes of pyridine derivatives with superoxide scavenging and antimicrobial activities

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Issued Date

2009

Resource Type

Article

File Type

application/pdf

ISSN

2235234

DOI

10.1016/j.ejmech.2009.03.033

Other identifier(s)

2-s2.0-67349216170

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

European Journal of Medicinal Chemistry. Vol 44, No.8 (2009), p.3259-3265

Suggested Citation

Suksrichavalit T., Prachayasittikul S., Nantasenamat C., Isarankura-Na-Ayudhya C., Prachayasittikul V. Copper complexes of pyridine derivatives with superoxide scavenging and antimicrobial activities. European Journal of Medicinal Chemistry. Vol 44, No.8 (2009), p.3259-3265. doi:10.1016/j.ejmech.2009.03.033 Retrieved from: https://hdl.handle.net/20.500.14740/5927

Title

Copper complexes of pyridine derivatives with superoxide scavenging and antimicrobial activities

Author(s)

Suksrichavalit T.
 Prachayasittikul S.
 Nantasenamat C.
 Isarankura-Na-Ayudhya C.
 Prachayasittikul V.

Abstract

Superoxide anions are reactive oxygen species that can attack biomolecules such as DNA, lipids and proteins to cause many serious diseases. This study reports the synthesis of copper complexes of nicotinic acid with related pyridine derivatives. The copper complexes were shown to possess superoxide dismutase (SOD) and antimicrobial activities. The copper complexes exerted SOD activity in range of 49.07-130.23 μM. Particularly, copper complex of nicotinic acid with 2-hydroxypyridine was the most potent SOD mimic with an IC50 of 49.07 μM. In addition, the complexes exhibited antimicrobial activity against Bacillus subtilis ATCC 6633 and Candida albicans ATCC 90028 with MIC range of 128-256 μg/mL. The SOD activities were well correlated with the theoretical parameters as calculated by density functional theory at the B3LYP/LANL2DZ level of theory. Interestingly, the SOD activity of the copper complexes was demonstrated to be inversely correlated with the electron affinity, but was well correlated with both HOMO and LUMO energies. The vitamin-metal complexes described in this report are great examples of the value-added benefits of vitamins for medicinal applications. © 2009 Elsevier Masson SAS. All rights reserved.

Subject(s)

2 aminopyridine
 Ampicillin
 Copper complex
 Nicotinic acid
 Nicotinic acid 2 aminopyridine copper complex
 Nicotinic acid 2 hydroxypyridine copper complex
 Nicotinic acid picolinic acid copper complex
 Picolinic acid
 Pyridine derivative
 Reactive oxygen metabolite
 Superoxide
 Superoxide dismutase
 Unclassified drug
 Aeromonas hydrophila
 Antimicrobial activity
 Antioxidant activity
 Article
 Bacillus cereus
 Bacillus subtilis
 Candida albicans
 Citrobacter freundii
 Density functional theory
 Drug synthesis
 Enzyme activity
 IC 50
 Infrared spectroscopy
 Listeria monocytogenes
 Minimum inhibitory concentration
 Molecular model
 Morganella morganii
 Nonhuman
 Plesiomonas shigelloides
 Quantum chemistry
 Salmonella enteritidis
 Shigella dysenteriae
 Streptococcus pyogenes
 Anti-Infective Agents
 Bacteria
 Biomimetics
 Copper
 Free Radical Scavengers
 Inhibitory Concentration 50
 Models, Molecular
 Molecular Conformation
 Organometallic Compounds
 Pyridines
 Quantum Theory
 Spectrophotometry, Infrared
 Superoxide Dismutase
 Superoxides
 Yeasts

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URI

https://hdl.handle.net/20.500.14740/5927

Collections

Scopus: Year 1983-2021

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