Publication: Minimum Contact Time of 1.25%, 2.5%, 5%, and 10% Benzoyl Peroxide for a Bactericidal Effect Against Cutibacterium acnes
1
0
Issued Date
2022
Resource Type
Language
eng
File Type
application/pdf
ISSN
11787015
Rights Holder(s)
Scopus
Bibliographic Citation
LEARN Journal: Language Education and Acquisition Research Network. Vol 15, No.1 (2022), p.383-408
Suggested Citation
Boonchaya P., Rojhirunsakool S., Kamanamool N., Khunkhet S., Yooyongsatit S., Udompataikul M., Taweechotipatr M. Minimum Contact Time of 1.25%, 2.5%, 5%, and 10% Benzoyl Peroxide for a Bactericidal Effect Against Cutibacterium acnes. LEARN Journal: Language Education and Acquisition Research Network. Vol 15, No.1 (2022), p.383-408. doi:10.2147/CCID.S359055 Retrieved from: https://hdl.handle.net/20.500.14740/9623
Abstract
Purpose: Benzoyl peroxide (BPO) is an effective acne treatment and has been used as a cleanser and short contact therapy. However, data on the minimum contact time of BPO needed to kill Cutibacterium acnes are lacking. Thus, the aim of this study was to determine the minimum contact time of commonly used BPO concentrations for bactericidal effects on C. acnes. Materials and Methods: An in vitro experimental study of clinically isolated C. acnes was performed to determine the minimal inhibitory concentration (MIC) of BPO using the broth microdilution method. Subsequently, the minimum contact times of various concentrations of BPO were evaluated, and their bactericidal effects were assessed by the plate count method. Results: The median MIC of BPO was 9375 µg/mL, which did not significantly differ between antibiotic-resistant and nonresistant C. acnes. The minimum contact time of BPO with C. acnes was significantly different among the BPO concentrations. For bactericidal activity against all isolates, 1.25%, 2.5%, 5%, and 10% BPO required 60 min, 15 min, 30 sec, and 30 sec, respectively. Conclusion: BPO demonstrated bactericidal activity against both antibiotic-resistant and antibiotic-susceptible C. acnes. The in vitro contact time needed to kill C. acnes was almost immediate with 5% or more BPO, but ≤ 2.5% BPO required longer contact times for bactericidal effects. © 2022 Boonchaya et al.