Publication: Urate-lowering therapy is associated with a reduced risk of arrhythmias: a systematic review and meta-analysis
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Issued Date
2024-04-01
Resource Type
ISSN
2093940X
eISSN
22334718
Scopus ID
2-s2.0-85190118527
Journal Title
Journal of Rheumatic Diseases
Volume
31
Issue
2
Start Page
108
End Page
115
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Rheumatic Diseases Vol.31 No.2 (2024) , 108-115
Suggested Citation
Waitayangkoon P., Leesutipornchai T., Techasatian W., Aiumtrakul N., Tanariyakul M., Arayangkool C., Kanthajan T., Nagamine T., Kewcharoen J. Urate-lowering therapy is associated with a reduced risk of arrhythmias: a systematic review and meta-analysis. Journal of Rheumatic Diseases Vol.31 No.2 (2024) , 108-115. 115. doi:10.4078/jrd.2023.0059 Retrieved from: https://hdl.handle.net/20.500.14740/20463
Corresponding Author(s)
Other Contributor(s)
Abstract
Objective: While urate-lowering therapy (ULT) is linked to increased cardioprotective benefits on primary prevention of cardiovascular events such myocardial infarction or heart failure, little is known regarding their effects on arrhythmia risk. The purpose of this study was to investigate the relationship between incident arrhythmias and ULT. Methods: We searched MEDLINE and Embase from inception to May 2023. Included studies were randomized controlled trials and cohort studies that compared the risk of cardiac arrhythmias among ULT users with non-ULT users. Results: A total of 12,420 patients from five studies were analyzed, comprising 7,359 subjects in the ULT group and 5,061 subjects in the non-ULT group. Our results showed that ULT users had significant reductions in the risk of arrhythmias (pooled relative risk [RR] 0.82, 95% confidence interval [CI]: 0.74~0.92, p<0.001, I2=0.0%) compared to non-ULT users. Subgroup analysis did not show that ULT users had a significant reduced risk of atrial fibrillation (pooled RR 0.76, 95% CI: 0.54~1.05, p=0.096 with I2=15.4%) compared to non-ULT users. Conclusion: ULT is associated with lower risk of overall arrhythmias. Further studies are warranted to confirm our findings.