Publication:
Molecular targets of apigenin in colorectal cancer cells: Involvement of p21, NAG-1 and p53

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

9598049

DOI

10.1016/j.ejca.2010.07.007

Other identifier(s)

2-s2.0-78649635941

Rights Holder(s)

Scopus

Bibliographic Citation

European Journal of Cancer. Vol 46, No.18 (2010), p.3365-3374

Suggested Citation

Zhong Y., Krisanapun C., Lee S.-H., Nualsanit T., Sams C., Peungvicha P., Baek S.J. Molecular targets of apigenin in colorectal cancer cells: Involvement of p21, NAG-1 and p53. European Journal of Cancer. Vol 46, No.18 (2010), p.3365-3374. doi:10.1016/j.ejca.2010.07.007 Retrieved from: https://hdl.handle.net/20.500.14740/7498

Title

Molecular targets of apigenin in colorectal cancer cells: Involvement of p21, NAG-1 and p53

Author(s)

Zhong Y.
 Krisanapun C.
 Lee S.-H.
 Nualsanit T.
 Sams C.
 Peungvicha P.
 Baek S.J.

Abstract

Persuasive epidemiological and experimental evidence suggests that dietary flavonoids have anti-cancer activity. Since conventional therapeutic and surgical approaches have not been able to fully control the incidence and outcome of most cancer types, including colorectal neoplasia, there is an urgent need to develop alternative approaches for the management of cancer. We sought to develop the best flavonoids for the inhibition of cell growth, and apigenin (flavone) proved to be the most promising compound in colorectal cancer cell growth arrest. Subsequently, we found that pro-apoptotic proteins (NAG-1 and p53) and cell cycle inhibitor (p21) were induced in the presence of apigenin, and kinase pathways, including PKCδ and ataxia telangiectasia mutated (ATM), play an important role in activating these proteins. The data generated by in vitro experiments were confirmed in an animal study using APC MIN+ mice. Apigenin is able to reduce polyp numbers, accompanied by increasing p53 activation through phosphorylation in animal models. Our data suggest apparent beneficial effects of apigenin on colon cancer. © 2010 Elsevier Ltd. All rights reserved.

Subject(s)

Antineoplastic agent
 Apigenin
 ATM protein
 Protein
 Protein kinase C gamma
 Protein nag 1
 Protein p21
 Protein p53
 Unclassified drug
 Animal experiment
 Animal model
 Antineoplastic activity
 Article
 Cancer cell
 Colorectal cancer
 Controlled study
 Enzyme activation
 Human
 Human cell
 In vitro study
 Liquid chromatography
 Mouse
 Nonhuman
 Priority journal
 Protein expression
 Protein phosphorylation
 Reverse transcription polymerase chain reaction
 Signal transduction
 Transient transfection
 Western blotting
 Animals
 Antineoplastic Agents
 Apigenin
 Apoptosis
 Cell Proliferation
 Colorectal Neoplasms
 Cyclin-Dependent Kinase Inhibitor p21
 Enzyme Inhibitors
 Growth Differentiation Factor 15
 Humans
 Mice
 Phosphorylation
 Phosphotransferases
 Tumor Cells, Cultured
 Tumor Suppressor Protein p53

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URI

https://hdl.handle.net/20.500.14740/7498

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Scopus: Year 1983-2021

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