Publication:
Herbal and dietary supplements related to diarrhea and acute kidney injury: A case report

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Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

15533840

DOI

10.1515/jcim-2016-0061

Other identifier(s)

2-s2.0-85015206551

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of Complementary and Integrative Medicine. Vol 14, No.1 (2017)

Suggested Citation

Wanitsriphinyo S., Tangkiatkumjai M. Herbal and dietary supplements related to diarrhea and acute kidney injury: A case report. Journal of Complementary and Integrative Medicine. Vol 14, No.1 (2017). doi:10.1515/jcim-2016-0061 Retrieved from: https://hdl.handle.net/20.500.14740/4221

Title

Herbal and dietary supplements related to diarrhea and acute kidney injury: A case report

Author(s)

Wanitsriphinyo S.
 Tangkiatkumjai M.

Abstract

There is very little evidence relating to the association of herbal medicine with diarrhea and the development of acute kidney injury (AKI). This study reports a case of diarrhea-induced AKI, possibly related to an individual ingesting copious amounts of homemade mixed fruit and herb puree. A 45-year-old Thai man with diabetes had diarrhea for 2 days, as a result of taking high amounts of a puree made up of eight mixed fruits and herbs over a 3-day period. He developed dehydration and stage 2 AKI, with a doubling of his serum creatinine. He had been receiving enalapril, as a prescribed medication, over one year. After he stopped taking both the puree and enalapril, and received fluid replacement therapy, within a week his serum creatinine had gradually decreased. The combination of puree, enalapril and AKI may also have induced hyperkalemia in this patient. Furthermore, the patient developed hyperphosphatemia due to his worsening kidney function, exacerbated by regularly taking some dietary supplements containing high levels of phosphate. His serum levels of potassium and phosphate returned to normal within a week, once the patient stopped both the puree and all dietary supplements, and had begun receiving treatment for hyperkalemia. The mixed fruit and herb puree taken by this man may have led to his diarrhea due to its effect; particularly if the patient was taking a high concentration of such a drink. Both the puree and enalapril are likely to attenuate the progression of kidney function. The causal relationship between the puree and AKI was probable (5 scores) assessed by the modified Naranjo algorithm. This is the first case report, as far as the authors are aware, relating the drinking of a mixed fruit and herbal puree to diarrhea and AKI in a patient with diabetes. This case can alert health care providers to the possibility that herbal medicine could induce diarrhea and develop acute kidney injury. © 2017 Walter de Gruyter GmbH, Berlin/Boston.

Subject(s)

Creatinine
 Enalapril
 Plant medicinal product
 Acute kidney failure
 Adult
 Article
 Case report
 Causal attribution
 Clinical feature
 Creatinine blood level
 Dehydration
 Diabetes mellitus
 Diarrhea
 Dietary supplement
 Disease duration
 Fluid therapy
 Fruit
 Herb
 Herbal medicine
 Human
 Hyperkalemia
 Male
 Middle aged
 Thai (people)
 Acute Kidney Injury
 Adverse effects
 Diabetes mellitus
 Diabetic Nephropathies
 Diarrhea
 Dietary supplement
 Phytotherapy
 Acute Kidney Injury
 Diabetes Mellitus
 Diabetic Nephropathies
 Diarrhea
 Dietary Supplements
 Enalapril
 Fruit
 Humans
 Male
 Middle Aged
 Phytotherapy
 Plant Preparations

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URI

https://hdl.handle.net/20.500.14740/4221

Collections

Scopus: Year 1983-2021

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