Publication:
Glycemic load is associated with oxidative stress among prevalent maintenance hemodialysis patients

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Issued Date

2014

Resource Type

Article

File Type

application/pdf

ISSN

9310509

DOI

10.1093/ndt/gft489

Other identifier(s)

2-s2.0-84899829842

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Nephrology Dialysis Transplantation. Vol 29, No.5 (2014), p.1047-1053

Suggested Citation

Limkunakul C., Sundell M.B., Pouliot B., Graves A.J., Shintani A., Ikizler T.A. Glycemic load is associated with oxidative stress among prevalent maintenance hemodialysis patients. Nephrology Dialysis Transplantation. Vol 29, No.5 (2014), p.1047-1053. doi:10.1093/ndt/gft489 Retrieved from: https://hdl.handle.net/20.500.14740/6275

Title

Glycemic load is associated with oxidative stress among prevalent maintenance hemodialysis patients

Author(s)

Limkunakul C.
 Sundell M.B.
 Pouliot B.
 Graves A.J.
 Shintani A.
 Ikizler T.A.

Abstract

Background High glycemic index (GI) and glycemic load (GL) are associated with increased levels of oxidative stress and systemic inflammation in the general population. Maintenance hemodialysis (MHD) patients are known to have excessive oxidative stress burden and inflammation. In this study, we examined the relationship between dietary GI or GL and markers of oxidative stress or inflammation among prevalent MHD patients. Methods A registered dietitian obtained GI, GL and other dietary data from 58 MHD patients. Two separate 24-h diet recalls (a hemodialysis day and a non-hemodialysis day) were analyzed using the Nutrition Data System for Research (NDS-R) software. Plasma or serum concentrations of F2-isoprostanes, high sensitivity C-reactive protein (hsCRP), leptin and adiponectin (ADPN) were measured in fasting state. Fat mass was measured by dual-energy X-ray absorptiometry (DEXA). Cross-sectional associations between GI, GL and markers of interest were examined by multiple regression analysis with adjustment for potential covariates. Results Mean (±SD) age, body mass index (BMI) and total trunk fat were 47 ± 12 years, 29.5 ± 6.8 kg/m2 and 16.4 ± 8.8 kg, respectively. Dietary GI was associated with trunk fat (r =-0.182, P = 0.05) but not with F2-isoprostanes and hsCRP. In contrast, GL was significantly associated with F2-isoprostanes (P = 0.002), in unadjusted analysis, which remained in adjusted analyses, adjusting for age and sex (P = 0.005), and after adjusting for BMI, trunk fat and waist/hip ratio (P = 0.004). Addition of leptin or ADPN did not alter the significance of the association. GL also correlated with hsCRP (P = 0.03), but this association was modified by BMI and trunk fat. Conclusions Dietary GL is significantly associated with markers of oxidative stress and inflammation among prevalent MHD patients, independent of the body composition and adipocytokines. These data indicate the importance of the contents of dietary nutrient intake composition and its potential role in determining the metabolic disturbances in MHD patients. © 2013 The Author.

Subject(s)

Adipocytokine
 Adiponectin
 Biological marker
 C reactive protein
 Insulin
 Isoprostane derivative
 Leptin
 Resistin
 Adult
 Article
 Body composition
 Body mass
 Cross-sectional study
 Dietary intake
 Disease association
 Fat mass
 Female
 Glycemic index
 Glycemic load
 Hemodialysis patient
 Human
 Inflammation
 Maintenance hemodialysis patient
 Major clinical study
 Male
 Obesity
 Oxidative stress
 Prevalence
 Priority journal
 Protein blood level
 Retrospective study
 Carbohydrate
 Diet
 Nutrition
 Oxidative stress
 Absorptiometry, Photon
 Adiponectin
 Adult
 Biological Markers
 Blood Glucose
 Cross-Sectional Studies
 Diet
 Female
 Glycemic Index
 Humans
 Inflammation
 Leptin
 Male
 Middle Aged
 Oxidative Stress
 Renal Dialysis
 Retrospective Studies

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URI

https://hdl.handle.net/20.500.14740/6275

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Scopus: Year 1983-2021

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