Publication:
Effect of Inhaling bergamot oil on depression-related behaviors in chronic stressed rats

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Issued Date

2015

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-84957609830

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 98, (2015), p.S152-S159

Suggested Citation

Saiyudthong S., Mekseepralard C. Effect of Inhaling bergamot oil on depression-related behaviors in chronic stressed rats. Journal of the Medical Association of Thailand. Vol 98, (2015), p.S152-S159. Retrieved from: https://hdl.handle.net/20.500.14740/6063

Title

Effect of Inhaling bergamot oil on depression-related behaviors in chronic stressed rats

Author(s)

Saiyudthong S.
 Mekseepralard C.

Abstract

Background: Bergamot essential oil (BEO) possesses sedation and anxiolytic properties similar to diazepam. After long period of exposure to stressors, including restrained stress, depressive-like behavior can be produced. BEO has been suggested to reduce depression. However, there is no scientific evidence supporting this property. Objective: To investigate the effect of BEO in chronic stressed rats on: 1) behavior related depressive disorder, 2) hypothalamic pituitary adrenal (HPA) axis response, and iii) brain-derived neurotrophic factor (BDNF) protein levels in hippocampus. Material and Method: Male Wistar rats, weighing 200 to 250 g, were induced chronic restrained stress 15 minutes daily for two weeks. For the next two weeks, these rats were divided into four groups, control-i.p., fluoxetine-i.p., control-inhale, and BEO-inhale. Fluoxetine (10 mg/kg i.p.) or saline was intraperitoneally administered daily while 2.5% BEO or saline was inhaled daily. At the end of the treatment, rats were assessed for depressive-like behavior using the forced swimming test (FST). After the behavioral test, the animals were immediately decapitated and trunk blood samples were collected for the measurement of corticosterone and adrenocorticotropic hormone (ACTH) levels and hippocampus was dissected and stored in a freezer at -80 °C until assay for BDNF protein. Results: BEO and fluoxetine significantly decreased the immobility time in the FST (p<0.05). Fluoxetine tended to decrease serum corticosterone and significantly (p<0.05) decreased serum ACTH while BEO had no effect on these two stress hormones. For BDNF protein determination, neither BEO nor fluoxetine had any effect on BDNF protein levels in hippocampus compared to their controls. Conclusion: The inhalation of BEO decrease behavior related depressive disorder similar to fluoxetine but has no effect on HPA axis response and BDNF protein levels in chronic restrained stress. © 2015, Medical Association of Thailand. All rights reserved.

Subject(s)

Bergamot oil
 Brain derived neurotrophic factor
 Corticosterone
 Corticotropin
 Fluoxetine
 Bergamot oil
 Brain derived neurotrophic factor
 Corticosterone
 Essential oil
 Vegetable oil
 Animal experiment
 Animal model
 Animal tissue
 Article
 Chronic stress
 Controlled study
 Depression
 Enzyme immunoassay
 Forced swim test
 Hypothalamus hypophysis adrenal system
 Immobilization stress
 Male
 Nonhuman
 Rat
 Animal
 Blood
 Depression
 Depressive Disorder
 Drug effects
 Hippocampus
 Hypophysis adrenal system
 Hypothalamus hypophysis system
 Mental stress
 Metabolism
 Wistar rat
 Animals
 Brain-Derived Neurotrophic Factor
 Corticosterone
 Depression
 Depressive Disorder
 Hippocampus
 Hypothalamo-Hypophyseal System
 Male
 Oils, Volatile
 Pituitary-Adrenal System
 Plant Oils
 Rats
 Rats, Wistar
 Stress, Psychological

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URI

https://hdl.handle.net/20.500.14740/6063

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Scopus: Year 1983-2021

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