Publication:
Phikud Navakot Modulates the Level of Pro-Inflammatory Mediators and the Protein Expression of SOD1 and 2 and the Nrf2/HO-1 Signaling Pathway in Rats with Acute Myocardial Infarction

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

1741427X

DOI

10.1155/2019/4823645

Other identifier(s)

2-s2.0-85073078632

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Evidence-based Complementary and Alternative Medicine. Vol 2019, (2019)

Suggested Citation

Gerdprasert O., Choomchuay N., Chantong B., Sutanthavibul N., Meksuriyen D., Nusuetrong P. Phikud Navakot Modulates the Level of Pro-Inflammatory Mediators and the Protein Expression of SOD1 and 2 and the Nrf2/HO-1 Signaling Pathway in Rats with Acute Myocardial Infarction. Evidence-based Complementary and Alternative Medicine. Vol 2019, (2019). doi:10.1155/2019/4823645 Retrieved from: https://hdl.handle.net/20.500.14740/5620

Title

Phikud Navakot Modulates the Level of Pro-Inflammatory Mediators and the Protein Expression of SOD1 and 2 and the Nrf2/HO-1 Signaling Pathway in Rats with Acute Myocardial Infarction

Author(s)

Gerdprasert O.
 Choomchuay N.
 Chantong B.
 Sutanthavibul N.
 Meksuriyen D.
 Nusuetrong P.

Abstract

Phikud Navakot (PN) is nine major herbs in a famous traditional Thai recipe namely "Yahom Navakot" used to treat cardiovascular disorders. This study investigated the cardioprotective effects of PN formula on isoproterenol-induced myocardial infarction (IMI) in Sprague-Dawley rats. Forty-five rats were randomly divided into nine groups (n = 5 per group): the control, the IMI, the IMI + propranolol, the control or the IMI + PN formula (PN ethanolic extract at doses of 64, 127, or 255 mg/kg) by oroesophageal gavage for 28 days. The ST segment and serum troponin T levels were significantly increased in IMI rats. PN did not eliminate tissue necrosis, infiltration of inflammatory cells, or interstitial edema in IMI rats. All doses of PN decreased (p<0.001) serum TNF-α and IL-6 levels. PN (127 and 255 mg/kg) up-regulated (p<0.05) heme oxygenase (HO)-1 expression, whereas PN (255 mg/kg) significantly increased superoxide dismutase (SOD) 1 and 2 expression, compared with IMI rats. Nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 expression significantly increased in IMI rats and IMI rats that received PN. PN formula possesses potential anti-inflammatory and antioxidant properties by modulating the levels of TNF-α, IL-6 and antioxidant enzymes. Our study reveals a novel cardioprotective effect of PN in IMI rats through the Nrf2/HO-1 signaling. © 2019 Orapin Gerdprasert et al.

Subject(s)

Alcohol
 Antiinflammatory agent
 Antioxidant
 Cardiovascular agent
 Catalase
 Copper zinc superoxide dismutase
 Glutathione peroxidase
 Heme oxygenase 1
 Herbaceous agent
 Interleukin 6
 Manganese superoxide dismutase
 Phikud navakot
 Propranolol
 Protective agent
 Transcription factor Nrf2
 Troponin T
 Tumor necrosis factor
 Unclassified drug
 Acute heart infarction
 Animal experiment
 Animal model
 Animal tissue
 Antiinflammatory activity
 Antioxidant activity
 Article
 Cell infiltration
 Controlled study
 Cytokine release
 Drug dose comparison
 Drug efficacy
 Drug mechanism
 Edema
 Enzyme activity
 Ethnopharmacology
 Heart muscle injury
 Heart muscle necrosis
 Heart protection
 Heart tissue
 Inflammation
 Inflammatory cell
 Inflammatory infiltrate
 Interstitial edema
 Isoproterenol-induced myocardial infarction
 Male
 Mediator release
 Nonhuman
 Oxidative stress
 Protein blood level
 Protein expression
 Rat
 Signal transduction
 ST segment
 Tissue necrosis
 Upregulation

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URI

https://hdl.handle.net/20.500.14740/5620

Collections

Scopus: Year 1983-2021

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