Publication:
Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilis

0
0

Issued Date

2016

Resource Type

Article

File Type

application/pdf

ISSN

1981528X

DOI

10.1016/j.bjp.2016.01.007

Other identifier(s)

2-s2.0-84975093399

Rights Holder(s)

Scopus

Bibliographic Citation

Revista Brasileira de Farmacognosia. Vol 26, No.3 (2016), p.312-320

Suggested Citation

Supasuteekul C., Nonthitipong W., Tadtong S., Likhitwitayawuid K., Tengamnuay P., Sritularak B. Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilis. Revista Brasileira de Farmacognosia. Vol 26, No.3 (2016), p.312-320. doi:10.1016/j.bjp.2016.01.007 Retrieved from: https://hdl.handle.net/20.500.14740/5443

Title

Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilis

Author(s)

Supasuteekul C.
 Nonthitipong W.
 Tadtong S.
 Likhitwitayawuid K.
 Tengamnuay P.
 Sritularak B.

Abstract

The leaves of Garcinia gracilis Pierre, Clusiaceae, have been used as flavouring materials in food, with no previous reports of their biological activities and chemical constituents. In this study, the methanolic extract of G. gracilis afforded three compounds namely apigenin-8-C-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranoside (1), 5-hydroxymethyl-2-furaldehyde, and vanillic acid. All of the isolates were initially evaluated for superoxide anion radical scavenging activity and α-glucosidase inhibitory effects. Compound 1, which was the major component, showed the most potent activities among these three isolates. Further biological evaluations revealed that compound 1 could prevent the pBR322 plasmid DNA damage induced by the photochemical reaction of riboflavin and protect P19-derived neurons from the oxidative stress condition induced by serum deprivation. It was concluded that the potent biological activities of G. gracilis could be attributed to the synergistic effect of compound 1 with other constituents found in the plant. © 2016 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.

Subject(s)

5 hydroxymethylfurfural
 Acarbose
 Alpha glucosidase
 Antioxidant
 Garcinia gracilis extract
 Glucopyranoside
 Glucose
 Glycoside
 Methanol
 Neuroprotective agent
 Plant extract
 Protein p19
 Quercetin
 Rhamnose
 Riboflavin
 Trolox C
 Unclassified drug
 Vanillic acid
 Antioxidant activity
 Article
 Biological activity
 Cell differentiation
 Cell isolation
 Cell viability
 DNA damage
 DPPH radical scavenging assay
 Drug potentiation
 Garcinia
 Genetic linkage
 Growth curve
 IC50
 Neuroprotection
 Oxidative stress
 Photooxidation
 Plant leaf

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/5443

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By