Publication:
The association of the APOC3 and APOA5 gene polymorphisms with dyslipidemia in Thais

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Issued Date

2021

Resource Type

Article

Language

eng

File Type

application/pdf

ISSN

1252208

DOI

10.35755/jmedassocthai.2021.S03.00010

Other identifier(s)

2-s2.0-85116034970

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 104, No.9 (2021), p.S15-S22

Suggested Citation

Chuenta W., Cheewaphan A., Lee B., Wannaiampikul S. The association of the APOC3 and APOA5 gene polymorphisms with dyslipidemia in Thais. Journal of the Medical Association of Thailand. Vol 104, No.9 (2021), p.S15-S22. doi:10.35755/jmedassocthai.2021.S03.00010 Retrieved from: https://hdl.handle.net/20.500.14740/3787

Title

The association of the APOC3 and APOA5 gene polymorphisms with dyslipidemia in Thais

Author(s)

Chuenta W.
 Cheewaphan A.
 Lee B.
 Wannaiampikul S.

Abstract

Background: Although the association between the apolipoprotein A5 (APOA5), and apolipoprotein C3 (APOC3) genetic variants with dyslipidemia have been extensively studied in various populations. However, the association between the apolipoprotein A5 (APOA5), and apolipoprotein C3 (APOC3) genetic variants with dyslipidemia was limited in Thai population. Objective: The present study was to examine whether APOA5 and APOC3 gene polymorphisms associated with increased risk of developing dyslipidemia in Thais. Materials and Methods: Two hundred participants were recruited in case-control studies, Four SNPs in APOC3 (rs2854116 T/C, rs2854117 C/T, rs5128 G/C) and APOA5 (rs651821 T/C) genes were genotyped by PCR-RFLP methods. Results: The results showed that polymorphism in rs651821 of APOA5 gene was significantly associated with high triglyceride levels (p=0.017). The risk of dyslipidemia increased for carrying T/C+C/C genotypes and C allele of rs651821 in APOA5 gene were 2.02 (OR: 2.02, 95% CI: 1.07 to 3.79, p=0.028) and 2.27 (OR: 2.27, 95% CI: 1.10 to 4.69, p=0.025), respectively. The haplotype analysis of variants in APOC3 (rs2854116, rs2854117, rs5128) and APOA5 (rs651821) genes, carrying with CTCC haplotype was significantly higher the risk of dyslipidemia (OR: 3.42, 95% CI: 1.23 to 9.49, p=0.019), compared with the common haplotype (TCGT). Conclusion: The risk allele (C allele) in rs651821 of APOA5 gene was associated with increasing risk of dyslipidemia by 2 times, and also haplotype carriers of APOC3 (rs2854116 (C), rs2854117 (T), rs5128 (C)) and APOA5 (rs651821 (C)) genes have higher risk of developing dyslipidemia by 3 times in Thai population. However, the association between SNPs in APOC3 gene and dyslipidemia was not observed in the present study. © JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND.

Subject(s)

Apolipoprotein A5
 Apolipoprotein A6
 Cholesterol
 High density lipoprotein cholesterol
 Low density lipoprotein cholesterol
 Triacylglycerol
 Unclassified drug
 Adult
 Anthropometric parameters
 Anthropometry
 APOA5 gene
 APOC3 gene
 Article
 Blood pressure monitoring
 Body weight
 Controlled study
 DNA extraction
 DNA polymorphism
 Dyslipidemia
 Female
 Gene
 Gene frequency
 Gene linkage disequilibrium
 Gene sequence
 Genetic association
 Genetic polymorphism
 Genetic variation
 Genotype phenotype correlation
 Haplotype
 Hardy Weinberg Equilibrium
 Human
 Intra-abdominal fat
 Major clinical study
 Male
 Middle aged
 Polymerase chain reaction
 Restriction fragment length polymorphism
 Single nucleotide polymorphism
 Spectrophotometry
 Thai (people)
 Waist circumference

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URI

https://hdl.handle.net/20.500.14740/3787

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Scopus: Year 1983-2021

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