Publication: Does Extending the Waiting Time of Low-Rectal Cancer Surgery after Neoadjuvant Chemoradiation Increase the Perioperative Complications?
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Issued Date
2016
Resource Type
File Type
application/pdf
ISSN
16876121
Other identifier(s)
2-s2.0-84990852977
Rights Holder(s)
Scopus
Bibliographic Citation
Gastroenterology Research and Practice. Vol 2016, (2016)
Suggested Citation
Timudom K., Phothong N., Akaraviputh T., Chinswangwatanakul V., Pongpaibul A., Petsuksiri J., Ithimakin S., Trakarnsanga A. Does Extending the Waiting Time of Low-Rectal Cancer Surgery after Neoadjuvant Chemoradiation Increase the Perioperative Complications?. Gastroenterology Research and Practice. Vol 2016, (2016). doi:10.1155/2016/7870815 Retrieved from: https://hdl.handle.net/20.500.14740/5950
Abstract
Background. Traditionally, rectal cancer surgery is recommended 6 to 8 weeks after completing neoadjuvant chemoradiation. Extending the waiting time may increase the tumor response rate. However, the perioperative complication rate may increase. The purpose of this study was to determine the association between extending the waiting time of surgery after neoadjuvant chemoradiation and perioperative outcomes. Methods. Sixty patients with locally advanced rectal cancer who underwent neoadjuvant chemoradiation followed by radical resection at Siriraj hospital between June 2012 and January 2015 were retrospectively analyzed. Demographic data and perioperative outcomes were compared between the two groups. Results. The two groups were comparable in term of demographic parameters. The mean time interval from neoadjuvant chemoradiation to surgery was 6.4 weeks in Group A and 11.7 weeks in Group B. The perioperative outcomes were not significantly different between Groups A and B. Pathologic examination showed a significantly higher rate of circumferential margin positivity in Group A than in Group B (30% versus 9.3%, resp.; P = 0.04). Conclusions. Extending the waiting to >8 weeks from neoadjuvant chemoradiation to surgery did not increase perioperative complications, whereas the rate of circumferential margin positivity decreased. © 2016 Kittinut Timudom et al.
Subject(s)
Antineoplastic agent
Adjuvant chemoradiotherapy
Adult
Advanced cancer
Anastomosis leakage
Article
Cancer chemotherapy
Cancer radiotherapy
Cancer surgery
Female
Histopathology
Human
Lymph vessel metastasis
Major clinical study
Male
Middle aged
Outcome assessment
Peroperative complication
Postoperative complication
Radical resection
Rectum cancer
Retrospective study
Thailand
Treatment indication
Wound infection
Adjuvant chemoradiotherapy
Adult
Advanced cancer
Anastomosis leakage
Article
Cancer chemotherapy
Cancer radiotherapy
Cancer surgery
Female
Histopathology
Human
Lymph vessel metastasis
Major clinical study
Male
Middle aged
Outcome assessment
Peroperative complication
Postoperative complication
Radical resection
Rectum cancer
Retrospective study
Thailand
Treatment indication
Wound infection