Publication:
Characteristics, treatment patterns, prognostic determinants and outcome of peripheral T cell lymphoma and natural killer/T cell non-Hodgkin Lymphoma in older patients: The result of the nationwide multi-institutional registry Thai Lymphoma Study Group

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Issued Date

2020

Resource Type

Article

File Type

application/pdf

ISSN

18794068

DOI

10.1016/j.jgo.2019.03.016

Other identifier(s)

2-s2.0-85063582476

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Geriatric Oncology. Vol 11, No.1 (2020), p.62-68

Suggested Citation

Wudhikarn K., Bunworasate U., Julamanee J., Lekhakula A., Ekwattanakit S., Khuhapinant A., Chuncharunee S., Niparuck P., Numbenjapon T., Prayongratana K., Kanitsap N., Wongkhantee S., Makruasi N., Wong P., Norasetthada L., Nawarawong W., Sirijerachai C., Chansung K., Suwanban T., Praditsuktavorn P., Intragumtornchai T., On Behalf Of Thai Lymphoma Study Group Characteristics, treatment patterns, prognostic determinants and outcome of peripheral T cell lymphoma and natural killer/T cell non-Hodgkin Lymphoma in older patients: The result of the nationwide multi-institutional registry Thai Lymphoma Study Group. Journal of Geriatric Oncology. Vol 11, No.1 (2020), p.62-68. doi:10.1016/j.jgo.2019.03.016 Retrieved from: https://hdl.handle.net/20.500.14740/4948

Title

Characteristics, treatment patterns, prognostic determinants and outcome of peripheral T cell lymphoma and natural killer/T cell non-Hodgkin Lymphoma in older patients: The result of the nationwide multi-institutional registry Thai Lymphoma Study Group

Author(s)

Wudhikarn K.
 Bunworasate U.
 Julamanee J.
 Lekhakula A.
 Ekwattanakit S.
 Khuhapinant A.
 Chuncharunee S.
 Niparuck P.
 Numbenjapon T.
 Prayongratana K.
 Kanitsap N.
 Wongkhantee S.
 Makruasi N.
 Wong P.
 Norasetthada L.
 Nawarawong W.
 Sirijerachai C.
 Chansung K.
 Suwanban T.
 Praditsuktavorn P.
 Intragumtornchai T.
 On Behalf Of Thai Lymphoma Study Group

Abstract

Introduction: Peripheral T cell NHL (PTCL) and natural killer/T cell NHL (NKTCL) are relatively rare disorders. Data on clinical presentation, treatment and outcome are limited especially in older age groups. Methods: We identified 127 patients with PTCL and NKTCL, excluding cutaneous T/NK cell lymphoma, aged over 60 years old from Thailand nationwide multicenter registry. Results: Of 127 patients, median age of diagnosis was 67 years old. Patients aged older than 75 years old had similar characteristics to younger (60–74 years old) but higher comorbidity index. Seventy-nine patients (62.2%) received intensive/definite multi-agent chemotherapy, however, the proportion was significant lower in older patients (70.4% vs 34.5%, p <. 001). After a median follow up duration of 17.3 months, 2-year progression free survival and overall survival were 38.1% and 48.5%. Univariate and multivariable analysis demonstrated older age, poor performance status and absence of definite multi-agent chemotherapy were associated with inferior survival. Definite multi-agent lymphoma specific chemotherapy was an independent factor for overall survival after adjustment for age, comorbidity index, performance status and prognostic index for T cell lymphoma. Conclusion: Despite overall poor prognosis of PTCL and NKTCL in older adults, chemotherapy could result in objective response and long-term survival in selected patients of this vulnerable age group thus emphasizing the importance of comprehensive geriatric evaluation. © 2019

Subject(s)

Asparaginase
 Cyclophosphamide
 Dexamethasone
 Doxorubicin
 Etoposide
 Ifosfamide
 Methotrexate
 Prednisolone
 Steroid
 Vincristine
 Adult
 Aged
 Aging
 Article
 Cancer chemotherapy
 Cancer combination chemotherapy
 Cancer prognosis
 Cancer radiotherapy
 Cancer registry
 Cohort analysis
 Comorbidity
 Controlled study
 Diarrhea
 Drug dose escalation
 Drug fatality
 Drug safety
 Febrile neutropenia
 Female
 Follow up
 Geriatric assessment
 Groups by age
 Human
 Ileus
 Infection
 Intensive care
 Long term survival
 Major clinical study
 Male
 Multiple cycle treatment
 Neuropathy
 Neutropenia
 NK T cell lymphoma
 Nonhodgkin lymphoma
 Oral mucositis
 Overall survival
 Peripheral T cell lymphoma
 Physical performance
 Polypharmacy
 Priority journal
 Progression free survival
 Thailand
 Thrombocytopenia
 Treatment outcome

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URI

https://hdl.handle.net/20.500.14740/4948

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Scopus: Year 1983-2021

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