Publication: Corneal abnormalities in diabetes
1
0
Issued Date
2001
Resource Type
File Type
application/pdf
ISSN
1252208
Other identifier(s)
2-s2.0-0035431965
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol 84, No.8 (2001), p.1075-1083
Suggested Citation
Siribunkum J., Kosrirukvongs P., Singalavanija A. Corneal abnormalities in diabetes. Journal of the Medical Association of Thailand. Vol 84, No.8 (2001), p.1075-1083. Retrieved from: https://hdl.handle.net/20.500.14740/6863
Author(s)
Abstract
Objective : To compare corneal thickness and endothelial morphology in patients with diabetes mellitus and age-matched normal subjects, and to determine whether the duration of diabetes mellitus, severity of diabetic retinopathy, and glycemic control are correlated with these measurements. Design : Single center, case-control study. Participants : Sixty eyes of thirty diabetic patients and sixty eyes of thirty healthy non-diabetic subjects were studied. Intervention : Corneal thickness was measured by ultrasonic pachymeter. Corneal endothelial morphology was examined with a contact specular microscope. Main Outcome Measures : Corneal endothelial cell density, mean cell area, coefficient of variation, percentages of hexagonal cells, and corneal thickness were measured. Results : There was statistically significant increased corneal endothelial cell density and decreased mean endothelial cell area in the diabetic patients. The diabetic corneas had an increased coefficient of variation of endothelial cell area, a decreased percentage of hexagonal endothelial cell and an increased corneal thickness compared with the control subjects, but these differences were not statistically significant. The duration of diabetes mellitus was significantly correlated with pleomorphism, polymegathism and corneal thickness. Severity of diabetic retinopathy was correlated with endothelial cell density, but these correlations were low. The corneal changes were not correlated with glycemic control. Conclusions : The diabetic corneas tended to be thicker and had more pleomorphism and polymegathism, though this was not statistically significant. Duration of diabetes mellitus correlated significantly with these corneal changes. This suggests that corneal changes should be evaluated and confirmed before intraocular surgery in chronic diabetic patients.
Subject(s)
Glycosylated hemoglobin
Adult
Age
Age distribution
Aged
Analysis of variance
Article
Case control study
Cell count
Classification
Cornea disease
Cornea endothelium
Diabetes mellitus
Diabetic retinopathy
Echography
Female
Hospitalization
Human
Image cytometry
Image processing
Male
Metabolism
Pathology
Prediction and forecasting
Regression analysis
Time
Adult
Age Distribution
Age Factors
Aged
Aged, 80 and over
Analysis of Variance
Case-Control Studies
Cell Count
Corneal Diseases
Diabetes Mellitus
Diabetic Retinopathy
Endothelium, Corneal
Female
Hemoglobin A, Glycosylated
Human
Image Cytometry
Image Processing, Computer-Assisted
Male
Middle Age
Predictive Value of Tests
Regression Analysis
Severity of Illness Index
Time Factors
Adult
Age
Age distribution
Aged
Analysis of variance
Article
Case control study
Cell count
Classification
Cornea disease
Cornea endothelium
Diabetes mellitus
Diabetic retinopathy
Echography
Female
Hospitalization
Human
Image cytometry
Image processing
Male
Metabolism
Pathology
Prediction and forecasting
Regression analysis
Time
Adult
Age Distribution
Age Factors
Aged
Aged, 80 and over
Analysis of Variance
Case-Control Studies
Cell Count
Corneal Diseases
Diabetes Mellitus
Diabetic Retinopathy
Endothelium, Corneal
Female
Hemoglobin A, Glycosylated
Human
Image Cytometry
Image Processing, Computer-Assisted
Male
Middle Age
Predictive Value of Tests
Regression Analysis
Severity of Illness Index
Time Factors