Publication:
Paclitaxel and carboplatin for large cell neuroendocrine carcinoma of the uterine cervix

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Issued Date

2007

Resource Type

Article

File Type

application/pdf

ISSN

13418076

DOI

10.1111/j.1447-0756.2007.00509.x

Other identifier(s)

2-s2.0-33847713390

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Obstetrics and Gynaecology Research. Vol 33, No.2 (2007), p.218-224

Suggested Citation

Tangjitgamol S., Manusirivithaya S., Choomchuay N., Leelahakorn S., Thawaramara T., Pataradool K., Suekwatana P. Paclitaxel and carboplatin for large cell neuroendocrine carcinoma of the uterine cervix. Journal of Obstetrics and Gynaecology Research. Vol 33, No.2 (2007), p.218-224. doi:10.1111/j.1447-0756.2007.00509.x Retrieved from: https://hdl.handle.net/20.500.14740/4721

Title

Paclitaxel and carboplatin for large cell neuroendocrine carcinoma of the uterine cervix

Author(s)

Tangjitgamol S.
 Manusirivithaya S.
 Choomchuay N.
 Leelahakorn S.
 Thawaramara T.
 Pataradool K.
 Suekwatana P.

Abstract

The prognosis of large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is generally poor despite multimodality of treatments. We report a case of advanced stage cervical LCNEC that showed definite response to paclitaxel/carboplatin, resulting in years of survival. The patient was referred to our institution after undergoing a simple hysterectomy with bilateral salpingo-oophorectomy in her local hospital because of a ruptured metastatic ovarian mass. She declined pelvic radiation treatment, so adjuvant chemotherapy (six cycles of paclitaxel/carboplatin) was given for the residual pelvic nodal diseases. Clinical complete remission was obtained, with a disease-free period of 19 months. Systemic recurrent diseases also showed partial response to the same drug regimen for months with only minimal toxicity. However, she subsequently had progressive diseases in the liver and brain and finally died at 44 months after primary diagnosis and 19 months after recurrent diseases. © 2007 The Authors.

Subject(s)

Carboplatin
 Cisplatin
 Etoposide
 Paclitaxel
 Adrenal metastasis
 Adult
 Article
 Aspiration biopsy
 Brain metastasis
 Cancer chemotherapy
 Cancer regression
 Cancer staging
 Cancer survival
 Case report
 Clinical feature
 Computer assisted tomography
 Disease free interval
 Drug response
 Drug substitution
 Female
 Histopathology
 Human
 Human tissue
 Hysterectomy
 Laboratory test
 Large cell carcinoma
 Liver metastasis
 Lymph node metastasis
 Multiple cycle treatment
 Neuroendocrine tumor
 Ovary tumor
 Recurrent disease
 Salpingooophorectomy
 Unspecified side effect
 Uterine cervix carcinoma
 Adult
 Antineoplastic Agents
 Antineoplastic Agents, Phytogenic
 Brain Neoplasms
 Carboplatin
 Carcinoma, Large Cell
 Carcinoma, Neuroendocrine
 Chemotherapy, Adjuvant
 Combined Modality Therapy
 Disease Progression
 Fatal Outcome
 Female
 Humans
 Liver Neoplasms
 Neoplasm Recurrence, Local
 Ovariectomy
 Paclitaxel
 Uterine Cervical Neoplasms

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URI

https://hdl.handle.net/20.500.14740/4721

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Scopus: Year 1983-2021

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