Publication:
Vascular endothelial growth factor-C expression as a biomarker of poor prognosis in esophageal squamous cell carcinoma: a meta-analysis

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Issued Date

2015

Resource Type

Article

File Type

application/pdf

ISSN

22965262

DOI

10.1159/000380776

Other identifier(s)

2-s2.0-84941046316

Rights Holder(s)

Scopus

Bibliographic Citation

Oncology research and treatment. Vol 38, No.3 (2015), p.110-114

Suggested Citation

Tullavardhana T., Akranurakkul P., Ungkitphaiboon W., Songtish D. Vascular endothelial growth factor-C expression as a biomarker of poor prognosis in esophageal squamous cell carcinoma: a meta-analysis. Oncology research and treatment. Vol 38, No.3 (2015), p.110-114. doi:10.1159/000380776 Retrieved from: https://hdl.handle.net/20.500.14740/6201

Title

Vascular endothelial growth factor-C expression as a biomarker of poor prognosis in esophageal squamous cell carcinoma: a meta-analysis

Author(s)

Tullavardhana T.
 Akranurakkul P.
 Ungkitphaiboon W.
 Songtish D.

Abstract

BACKGROUND: Vascular endothelial growth factor C (VEGF-C) is involved in the development and progression of tumor angio-/lymphangiogenesis. The purpose of this study is to evaluate whether VEGF-C expression is an indicator of aggressiveness and poor prognosis of esophageal squamous cell carcinoma (ESCC).METHOD: A meta-analysis was conducted to investigate the association between VEGF-C expression with clinicopathological characteristics and survival of ESCC patients. The dataset was defined by searching PubMed, Embase, Google Scholar, and the Cochrane database for appropriate articles published until April 2014.RESULT: The final analysis was made from 9 studies, including 656 ESCC patients. Positive VEGF-C expression was defined by immunohistochemistry (IHC) or mRNA expression analysis. The results demonstrated that VEGF-C expression was significantly associated with advanced-stage disease (odds ratio (OR) = 2.29, 95% confidence interval (CI) = 1.37-3.84, P = 0.002), deeper tumor invasion, lymph node metastasis, and lymphatic invasion. The 5-year survival of VEGF-C expression-negative patients was found to be better than that of VEGF-C expression-positive patients (OR = 0.35, 95% CI = 0.21-0.58, P < 0.0001). However, there was no significant association between the VEGF-C expression levels and either poorer tumor differentiation or vascular invasion.CONCLUSION: The results of the meta-analysis strongly indicate that VEGF-C expression could function as a marker for predicting the aggressiveness and prognosis of ESCC. © 2015 S. Karger GmbH, Freiburg.

Subject(s)

Messenger RNA
 Tumor marker
 Vasculotropin C
 VEGFC protein, human
 VEGFC protein, human
 VEGFC protein, human
 Carcinoma, Squamous Cell
 Esophageal Neoplasms
 Gene expression regulation
 Genetics
 Human
 Immunohistochemistry
 Lymph node metastasis
 Meta analysis
 Metabolism
 Mortality
 Physiology
 Polymerase chain reaction
 Prognosis
 Survival rate
 Biomarkers, Tumor
 Biomarkers, Tumor
 Biomarkers, Tumor
 Carcinoma, Squamous Cell
 Carcinoma, Squamous Cell
 Carcinoma, Squamous Cell
 Esophageal Neoplasms
 Esophageal Neoplasms
 Esophageal Neoplasms
 Gene Expression Regulation, Neoplastic
 Gene Expression Regulation, Neoplastic
 Gene Expression Regulation, Neoplastic
 Humans
 Humans
 Humans
 Immunohistochemistry
 Immunohistochemistry
 Immunohistochemistry
 Lymphatic Metastasis
 Lymphatic Metastasis
 Lymphatic Metastasis
 Polymerase Chain Reaction
 Polymerase Chain Reaction
 Polymerase Chain Reaction
 Prognosis
 Prognosis
 Prognosis
 RNA, Messenger
 RNA, Messenger
 RNA, Messenger
 Survival Rate
 Survival Rate
 Survival Rate
 Vascular Endothelial Growth Factor C
 Vascular Endothelial Growth Factor C
 Vascular Endothelial Growth Factor C

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URI

https://hdl.handle.net/20.500.14740/6201

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Scopus: Year 1983-2021

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