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γ-Mangostin increases serotonin 2A/2C, muscarinic, histamine and bradykinin receptor mRNA expression

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dc.contributor.authorSukma M.
dc.contributor.authorTohda M.
dc.contributor.authorSuksamran S.
dc.contributor.authorTantisira B.
dc.date.accessioned2021-04-05T03:35:25Z
dc.date.available2021-04-05T03:35:25Z
dc.date.issued2011
dc.date.issuedBE2554
dc.description.abstractAim of the study: γ-Mangostin is a xanthone found in the fruit hulls of Garcinia mangostana L., which have long been used in Southeast Asia as a traditional medicine for the treatment of abdominal pain, dysentery, wound infections, fever and convulsions. Recent studies have revealed that γ-mangostin exhibits a variety of pharmacological activities, including serotonin 2 (5-HT 2) receptor antagonism, anti-inflammatory effects and analgesic effects. To explore the mechanism of γ-mangostin responsible for these pharmacological activities, especially its effects on some related receptors, we investigated the effects of γ-mangostin on 5-HT 2, histamine (H 1) and bradykinin (BK 2) receptor gene expression in neuroblastoma (NG 108-15) cells in vitro. Additionally, to extend the study of the pharmacological properties, we examined the effect of γ-mangostin on the muscarinic (M 4) receptor. Materials and methods: NG 108-15 cells were cultured in vitro and treated with γ-mangostin or a 5-HT 2 receptor antagonist (either imipramine or ketanserin). Then, the levels of mRNA for 5-HT 2A/2C receptors were evaluated by semi-quantitative RT-PCR. The preventive effect of serotonin on the enhancement effects was also revealed. Additionally, the effects of γ-mangostin on the muscarinic, histamine and bradykinin receptors were determined. Results: Chronic application of γ-mangostin at a concentration of 0.1 μM induced a significant increase in the level of 5-HT 2A/2C receptor mRNA. These effects were prevented by serotonin. Moreover, γ-mangostin up-regulated the M 4, H 1 and BK 2 receptors. Conclusion: The ability of γ-mangostin to enhance the expression of 5-HT 2A/2C, muscarinic, histamine and bradykinin receptor mRNA suggests that this compound has antagonistic effects. These pharmacological properties may partly account for the benefits of using mangosteen in the treatment of inflammation, pain and neuropsychiatric symptoms. © 2011 Elsevier Ireland Ltd. All rights reserved.
dc.format.mimetypeapplication/pdf
dc.identifier.citationJournal of Ethnopharmacology. Vol 135, No.2 (2011), p.450-454
dc.identifier.doi10.1016/j.jep.2011.03.039
dc.identifier.issn3788741
dc.identifier.other2-s2.0-79955680237
dc.identifier.urihttps://hdl.handle.net/20.500.14740/7329
dc.rights.holderScopus
dc.subject.otherBradykinin B2 receptor
dc.subject.otherGamma mangostin
dc.subject.otherHistamine H1 receptor
dc.subject.otherMessenger RNA
dc.subject.otherMuscarinic M4 receptor
dc.subject.otherSerotonin 2A receptor
dc.subject.otherSerotonin 2C receptor
dc.subject.otherUnclassified drug
dc.subject.otherXanthone derivative
dc.subject.otherArticle
dc.subject.otherCancer cell culture
dc.subject.otherDrug effect
dc.subject.otherDrug mechanism
dc.subject.otherNeuroblastoma cell
dc.subject.otherProtein expression
dc.subject.otherUpregulation
dc.subject.otherCell Line
dc.subject.otherReceptors, Cell Surface
dc.subject.otherReverse Transcriptase Polymerase Chain Reaction
dc.subject.otherRNA, Messenger
dc.subject.otherXanthones
dc.subject.otherGarcinia mangostana
dc.titleγ-Mangostin increases serotonin 2A/2C, muscarinic, histamine and bradykinin receptor mRNA expression
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79955680237&doi=10.1016%2fj.jep.2011.03.039&partnerID=40&md5=8f79d2f2b4270de8e21db6d90c1237af

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