Publication: A comparative study on the effect of alcohol-based hand sanitizers in spray and gel formulation on the skin: A prospective, randomised, crossover trial
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Issued Date
2024-04-01
Resource Type
ISSN
01051873
eISSN
16000536
Scopus ID
2-s2.0-85179311500
Pubmed ID
38086328
Journal Title
Contact Dermatitis
Volume
90
Issue
4
Start Page
394
End Page
401
Rights Holder(s)
SCOPUS
Bibliographic Citation
Contact Dermatitis Vol.90 No.4 (2024) , 394-401
Suggested Citation
Suwanchai C., Udompataikul M., Kamanamool N., Kanokrungsee S. A comparative study on the effect of alcohol-based hand sanitizers in spray and gel formulation on the skin: A prospective, randomised, crossover trial. Contact Dermatitis Vol.90 No.4 (2024) , 394-401. 401. doi:10.1111/cod.14476 Retrieved from: https://hdl.handle.net/20.500.14740/20462
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Abstract
Background: Many formulations of Alcohol-based hand rubs (ABHRs), such as liquid, gel, and spray have been developed and used for preventing infections. This study aimed to compare skin irritation from using ABHRs in gel and spray formulations. Method: This was a prospective, randomised, crossover trial conducted to investigate the effect of skin irritation caused by ABHRs in gel compared to spray formulation after 21 days of using each formulation. Clinical outcomes were assessed using subjective Larson's skin assessment score and Frosch and Kligman observer skin assessment score, as well as bioengineering measures: transepidermal water loss (TEWL) and skin capacitance on days 3, 7, 14, and 21. Results: Among 38 participants, both formulations showed no significant change in clinical scores and skin capacitance during the study. However, TEWL increased significantly from baseline on day 3 (p = 0.029) for the spray formulation and on day 21 (p = 0.019) for the gel formulation, with no statistically significant difference between the formulations (p = 0.46). Conclusion: Our research supports the safety of gel and spray ABHRs for regular use, with the only potential issue being mild skin irritation. For those with sensitive skin, the gel formulation is preferable.