Publication:
Expression of oral cytokines in HIV-infected subjects with long-term use of antiretroviral therapy

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Issued Date

2014

Resource Type

Article

File Type

application/pdf

ISSN

1354523X

DOI

10.1111/odi.12135

Other identifier(s)

2-s2.0-84896076057

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Oral Diseases. Vol 20, No.3 (2014), p.e57-e64

Suggested Citation

Nittayananta W., Amornthatree K., Kemapunmanus M., Talungchit S., Sriplung H. Expression of oral cytokines in HIV-infected subjects with long-term use of antiretroviral therapy. Oral Diseases. Vol 20, No.3 (2014), p.e57-e64. doi:10.1111/odi.12135 Retrieved from: https://hdl.handle.net/20.500.14740/6280

Title

Expression of oral cytokines in HIV-infected subjects with long-term use of antiretroviral therapy

Author(s)

Nittayananta W.
 Amornthatree K.
 Kemapunmanus M.
 Talungchit S.
 Sriplung H.

Abstract

Objectives: The objectives of this study were to determine (i) the expression of oral pro-inflammatory cytokines in HIV-infected subjects compared with non-HIV individuals, (ii) the cytokine expression in the subjects with antiretroviral therapy (ART) compared with those without ART, and (iii) factors associated with the expression of the cytokines. Materials and methods: Oral examination was performed and saliva samples were collected and analyzed for the expression of pro-inflammatory cytokines using ELISA. Logistic regression analysis was performed to determine the association between HIV/ART status and the cytokine expression. Results: One hundred and fifty-seven HIV-infected subjects with and without ART, and 50 non-HIV individuals were enrolled. TNF-α and IL-6 in saliva were significantly decreased, while IL-8 was significantly increased in HIV infection (P < 0.05). Changes in the expression of IL-8 were also observed between HIV-infected subjects who were and were not on ART (P < 0.05). Duration of HIV infection and smoking was significantly associated with the expression of pro-inflammatory cytokines in saliva (P < 0.05). Conclusion: Oral innate immunity is affected by HIV infection and use of ART. IL-8 may be the useful biomarker to identify subjects at risk of infection and malignant transformation due to HIV infection and long-term use of ART. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Subject(s)

Interleukin 6
 Interleukin 8
 Nonnucleoside reverse transcriptase inhibitor
 Proteinase inhibitor
 RNA directed DNA polymerase inhibitor
 Tumor necrosis factor alpha
 Anti human immunodeficiency virus agent
 Cytokine
 Adult
 Antiviral therapy
 Article
 CD4 lymphocyte count
 Comparative study
 Controlled study
 Cross-sectional study
 Disease association
 Disease duration
 Drinking behavior
 Female
 Flow rate
 Hairy leukoplakia
 Health status
 Human
 Human immunodeficiency virus infected patient
 Human immunodeficiency virus infection
 Hyperpigmentation
 Long term care
 Major clinical study
 Male
 Middle aged
 Mouth lesion
 Oral bleeding
 Periodontal pocket
 Priority journal
 Protein expression
 Saliva analysis
 Smoking
 Stomatitis
 Thrush
 Virus load
 Biosynthesis
 Chemistry
 HIV Infections
 Metabolism
 Saliva
 Time factor
 Young adult
 Adult
 Anti-HIV Agents
 Cross-Sectional Studies
 Cytokines
 Female
 HIV Infections
 Humans
 Male
 Middle Aged
 Saliva
 Time Factors
 Young Adult

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URI

https://hdl.handle.net/20.500.14740/6280

Collections

Scopus: Year 1983-2021

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