Publication:
Allylxanthone derivatives as xanthine oxidase inhibitors: Synthesis, biological evaluation and molecular docking study

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Issued Date

2018

Resource Type

Article

File Type

application/pdf

ISSN

0970020X

DOI

10.13005/ojc/340104

Other identifier(s)

2-s2.0-85043773790

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Oriental Journal of Chemistry. Vol 34, No.1 (2018), p.38-44

Suggested Citation

Khammee T., Jongsu W., Kuno M., Suksamrarn S. Allylxanthone derivatives as xanthine oxidase inhibitors: Synthesis, biological evaluation and molecular docking study. Oriental Journal of Chemistry. Vol 34, No.1 (2018), p.38-44. doi:10.13005/ojc/340104 Retrieved from: https://hdl.handle.net/20.500.14740/3900

Title

Allylxanthone derivatives as xanthine oxidase inhibitors: Synthesis, biological evaluation and molecular docking study

Author(s)

Khammee T.
 Jongsu W.
 Kuno M.
 Suksamrarn S.

Abstract

Gout is one of the most severe health problems of the aged and is caused by high levels of uric acid in the blood. The inhibition of Xanthine oxidase (XO) is one strategy to retain gout disease. Oxygenated xanthones and derivatives have been shown many important biological activities. However, some xanthones have the small amount of nature and its sulfur analogs, thioxanthone has not been well studied in their bioactivity. A series of hydroxyxanthones and allylxanthones analogous 3-5 have been synthesized and screened for their anti-XO activity. Leads to the discovery of 2,4-diallyl-1,3-dihydroxythioxanthone (5b) as the most active inhibitor with IC50 = 0.69±0.02 mM. Consequent molecular docking analysis by AutoDock 4.2 indicated that the most active compound (5b) inhibits XO by accommodated at the binding site of Xanthine oxidase. © 2017 Pensoft Publishers. All Rights Reserved.

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URI

https://hdl.handle.net/20.500.14740/3900

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Scopus: Year 1983-2021

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