Publication:
Encapsulation of monomyristin into polymeric nanoparticles improved its in vitro antiproliferative activity against cervical cancer cells

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

9277765

DOI

10.1016/j.colsurfb.2018.12.062

Other identifier(s)

2-s2.0-85058968630

Rights Holder(s)

Scopus

Bibliographic Citation

Colloids and Surfaces B: Biointerfaces. Vol 176, (2019), p.9-17

Suggested Citation

Boondireke S., Léonard M., Durand A., Thanomsub Wongsatayanon B. Encapsulation of monomyristin into polymeric nanoparticles improved its in vitro antiproliferative activity against cervical cancer cells. Colloids and Surfaces B: Biointerfaces. Vol 176, (2019), p.9-17. doi:10.1016/j.colsurfb.2018.12.062 Retrieved from: https://hdl.handle.net/20.500.14740/5395

Title

Encapsulation of monomyristin into polymeric nanoparticles improved its in vitro antiproliferative activity against cervical cancer cells

Author(s)

Boondireke S.
 Léonard M.
 Durand A.
 Thanomsub Wongsatayanon B.

Abstract

The cytotoxicity of monomyristin (MM), a monoacylglycerol, was investigated against cervical cancer cells (HeLa) and two normal cells (Vero and endometrial epithelial cells). MM exhibited cytotoxicity specifically to HeLa cells and not against normal cells except at the highest investigated doses (> 500 μg/mL). MM was showed to increase apoptotic dead cells by intrinsic mitochondrial pathway. To overcome the poor water solubility of MM and increase its efficacy against HeLa cells, MM was encapsulated into dextran-covered polylactide (PLA) nanoparticles (NPs). NPs comprised a PLA core which encapsulated MM and a superficial layer of dextran loops which was used for conjugating a protein, transferrin (Tf), known to be overexpressed on cancer cells’ surface. Encapsulation of MM into NPs increased its cytotoxicity against HeLa cells at lower doses of MM than free MM. Additionally, the presence of conjugated Tf further increased the cytotoxicity of MM against HeLa cells as compared to non-conjugated NPs. Remarkably, both conjugated and non-conjugated MM loaded NPs were safe to normal cells (Vero and endometrial). © 2018 Elsevier B.V.

Subject(s)

Cytotoxicity
 Dextran
 Diseases
 Lanthanum compounds
 Nanoparticles
 Anti-proliferative activities
 Cervical cancer cells
 Cervical cancers
 Mitochondrial pathways
 Monomyristin
 Polymeric nanoparticles
 Targeting
 Transferrin
 Cytology
 Dextran
 Monoacylglycerol
 Monomyristin
 Nanoparticle
 Polylactide
 Polymer
 Transferrin
 Unclassified drug
 Water
 Antineoplastic agent
 Drug carrier
 Monoacylglycerol
 Nanoparticle
 Polymer
 Animal cell
 Antiproliferative activity
 Apoptosis
 Article
 Cervical cancer cell line
 Controlled study
 Cytotoxicity
 Drug conjugation
 Drug delivery system
 Drug efficacy
 Drug solubility
 Female
 HeLa cell line
 Human
 Human cell
 In vitro study
 Mitochondrion
 Nanoencapsulation
 Nonhuman
 Priority journal
 Protein expression
 Signal transduction
 Vero cell line
 Animal
 Cell culture
 Cell proliferation
 Chemistry
 Chlorocebus aethiops
 Drug effect
 Drug screening
 Metabolism
 Pathology
 Surface property
 Uterine cervix tumor
 Animals
 Antineoplastic Agents
 Apoptosis
 Cell Proliferation
 Cells, Cultured
 Cercopithecus aethiops
 Drug Carriers
 Drug Screening Assays, Antitumor
 Female
 HeLa Cells
 Humans
 Monoglycerides
 Nanoparticles
 Polymers
 Surface Properties
 Uterine Cervical Neoplasms
 Vero Cells

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URI

https://hdl.handle.net/20.500.14740/5395

Collections

Scopus: Year 1983-2021

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