Publication: Distance-based paper device using polydiacetylene liposome as a chromogenic substance for rapid and in-field analysis of quaternary ammonium compounds
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Issued Date
2020
Resource Type
File Type
application/pdf
ISSN
16182642
Other identifier(s)
2-s2.0-85084230673
Rights Holder(s)
Scopus
Bibliographic Citation
Analytical and Bioanalytical Chemistry. Vol 412, No.13 (2020), p.3221-3230
Suggested Citation
Chutvirasakul B., Nuchtavorn N., Macka M., Suntornsuk L. Distance-based paper device using polydiacetylene liposome as a chromogenic substance for rapid and in-field analysis of quaternary ammonium compounds. Analytical and Bioanalytical Chemistry. Vol 412, No.13 (2020), p.3221-3230. doi:10.1007/s00216-020-02583-y Retrieved from: https://hdl.handle.net/20.500.14740/4580
Author(s)
Abstract
This work presents an affordable distance-based microfluidic paper-based device (μPAD), using polydiacetylene (PDA) liposome as a chromogenic substance with a smartphone-based photo editor, for rapid and in-field analysis of quaternary ammonium compounds (QACs) (e.g., didecyldimethylammonium chloride (DDAC), benzyldimethyltetradecyl ammonium chloride (BAC), and cetylpyridinium chloride (CPC)). In-field analysis of these compounds is important to ensure their antimicrobial activity and user safety since they are widely utilized as disinfectants in households and hospitals. The μPAD featured a thermometer-like shape consisting of a sample reservoir and a microchannel as the detection zone, which was pre-deposited with PDA liposome. The color change from blue to red appeared in the presence of QACs and the color bar lengths were proportional to the QAC concentrations. Reactions of QACs with the PDA required a specific pH range (from pH 4.0 to 10.0) and a readout time of 7 min. Analytical performance characteristics of the device were tested with DDAC, BAC, and CPC showing acceptable specificity, accuracy (96.1–109.4%), and precision (%RSDs ≤ 9.3%). Limits of detection and quantitation were in the ranges of 20 to 80 and 70 to 250 μM, respectively. Feasibility of the newly developed device was demonstrated for in-field analysis of QACs in fumigation solution providing comparable results with those obtained from a colorimetric assay (P > 0.05). The proposed device shows potentials for further applications of other analytes since it offers speed, simplicity, and affordability for in-field analysis, especially in remote areas where expertise, resources, and infrastructures are limited. [Figure not available: see fulltext.]. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Subject(s)
Ammonium compounds
Chlorine compounds
Color
Colorimetry
Polyacetylenes
Smartphones
Ammonium chloride
Analytical performance
Anti-microbial activity
Cetylpyridinium Chloride
Colorimetric assays
Limits of detection and quantitation
Paper based devices
Quaternary ammonium compound
Colorimetric analysis
Chlorine compounds
Color
Colorimetry
Polyacetylenes
Smartphones
Ammonium chloride
Analytical performance
Anti-microbial activity
Cetylpyridinium Chloride
Colorimetric assays
Limits of detection and quantitation
Paper based devices
Quaternary ammonium compound
Colorimetric analysis