Publication: Comparison of equations for the calculation of low-density lipoprotein cholesterol in thai population
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Issued Date
2021
Resource Type
Language
eng
File Type
application/pdf
ISSN
9769668
Other identifier(s)
2-s2.0-85111269349
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Journal of Natural Science, Biology and Medicine. Vol 12, No.2 (2021), p.224-229
Suggested Citation
Rerksuppaphol L., Rerksuppaphol S. Comparison of equations for the calculation of low-density lipoprotein cholesterol in thai population. Journal of Natural Science, Biology and Medicine. Vol 12, No.2 (2021), p.224-229. doi:10.4103/jnsbm.jnsbm-53-21 Retrieved from: https://hdl.handle.net/20.500.14740/6451
Author(s)
Abstract
Background: Low-density lipoprotein cholesterol (LDL-C) has been established as a major risk factor for cardiovascular diseases. Various equations have been proposed for LDL-C calculation; however, the accuracy of these equations varies among different ethnicities. This study aimed to assess the accuracy and concordance of LDL-C equations for dyslipidemia classifications in Thai adults. Materials and Methods: The lipid profiles of 1091 healthy Thai adults were measured using a homogenous enzymatic assay. The estimated LDL-C equations by Friedewald, Ahmadi, Anandaraja, Chen, Cordova, Densethakul, Hattori, Martin, Puavillai, Sampson, and Vujovic were compared to directly measured LDL-C using Pearson's correlation test. Cohen's kappa statistic was also used to test the concordance of the LDL-C equations with directly measured LDL-C levels, according to the standard guidelines for blood cholesterol management. Results: The LDL-C values calculated by Friedewald, Sampson, and Chen equations showed a high degree of correlation and values close to directly measured LDL-C levels with mean differences ranging from-0.04 to 0.07 mmol/L. All these three equations had a high degree of concordances with directly measured LDL-C levels for classifying the degree of dyslipidemia. Conclusion: Friedewald, Sampson, and Chen equations showed better estimations of LDL-C levels and had higher accuracy in classifying the degree of LDL-C strata than other equations in the Thai population. © 2021 Wolters Kluwer Medknow Publications. All rights reserved.