Publication:
The effects of oral vitamin D supplement on atopic dermatitis: A clinical trial with staphylococcus aureus colonization determination

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Issued Date

2015

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-84957708772

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 98, (2015), p.S23-S30

Suggested Citation

Udompataikul M., Huajai S., Chalermchai T., Taweechotipatr M., Kamanamool N. The effects of oral vitamin D supplement on atopic dermatitis: A clinical trial with staphylococcus aureus colonization determination. Journal of the Medical Association of Thailand. Vol 98, (2015), p.S23-S30. Retrieved from: https://hdl.handle.net/20.500.14740/6054

Title

The effects of oral vitamin D supplement on atopic dermatitis: A clinical trial with staphylococcus aureus colonization determination

Author(s)

Udompataikul M.
 Huajai S.
 Chalermchai T.
 Taweechotipatr M.
 Kamanamool N.

Abstract

Background: An increase in Staphylococcus aureus skin colonization in atopic dermatitis patients resulted from the reduction of cathelicidin production in these patients. Recently, an in vivo study demonstrated that vitamin D could stimulate cathelicidin production. Oral supplements of vitamin D might be beneficial in atopic dermatitis. Objective: To determine the effects of oral vitamin D supplements on clinical impact including Staphylococcus aureus skin colonization evaluation in atopic dermatitis patients. Material and Method: Twenty-four atopic dermatitis patients were included in this double-blind, placebo-controlled study. They were randomly assigned into 2 groups for oral 2,000 IUs/day of vitamin D2 supplement and placebo. The lesional swab culture for S. aureus was done at week 0, 2 and 4. Clinical outcomes were assessed by SCORAD score, mexameter for erythema index and konometer for conductance were done at week 0, 2 and 4. Serum vitamin D levels were also determined at week 0 and 4. Results: Twenty patients completed the protocol. S. aureus skin colonization, SCORAD score and erythema index were significantly reduced from baseline to week 4 for vitamin D treated group comparing with placebo (p = 0.022, 0.028 and 0.014, respectively). There was an inverse correlation between serum vitamin D levels with S. aureus skin colonization and SCORAD score (r = -1.0, p<0.001). Conclusion: Oral vitamin D supplement could reduce skin colonization of S.aureus and demonstrated the clinical improvement of patients with atopic dermatitis. © 2015, Medical Association of Thailand. All rights reserved.

Subject(s)

25 hydroxyvitamin D
 Cathelicidin
 Ergocalciferol
 Placebo
 Vitamin
 Vitamin D
 Adolescent
 Adult
 Article
 Assessment of humans
 Atopic dermatitis
 Child
 Clinical article
 Colorimetry
 Controlled study
 Double blind procedure
 Drug efficacy
 Erythema
 Female
 Human
 Male
 Preschool child
 Pruritus
 Randomized controlled trial
 School child
 SCORAD score
 Skin conductance
 Skin edema
 Staphylococcus aureus
 Staphylococcus infection
 Vitamin supplementation
 Dermatitis, Atopic
 Diet supplementation
 Drug effects
 Infant
 Isolation and purification
 Microbiology
 Pathology
 Skin
 Staphylococcal Infections
 Adolescent
 Child
 Child, Preschool
 Dermatitis, Atopic
 Dietary Supplements
 Double-Blind Method
 Female
 Humans
 Infant
 Male
 Skin
 Staphylococcal Infections
 Staphylococcus aureus
 Vitamin D
 Vitamins

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URI

https://hdl.handle.net/20.500.14740/6054

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Scopus: Year 1983-2021

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