Publication: A cream containing linoleic acid, 5% dexpanthenol and ceramide in the treatment of atopic dermatitis
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Issued Date
2024-12-01
Resource Type
ISSN
0125877X
eISSN
22288694
Scopus ID
2-s2.0-85214854405
Pubmed ID
33865303
Journal Title
Asian Pacific Journal of Allergy and Immunology
Volume
42
Issue
4
Start Page
361
End Page
367
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology Vol.42 No.4 (2024) , 361-367
Suggested Citation
Somjorn P., Kamanamool N., Kanokrungsee S., Rojhirunsakool S., Udompataikul M. A cream containing linoleic acid, 5% dexpanthenol and ceramide in the treatment of atopic dermatitis. Asian Pacific Journal of Allergy and Immunology Vol.42 No.4 (2024) , 361-367. 367. doi:10.12932/ap-230920-0969 Retrieved from: https://hdl.handle.net/20.500.14740/20898
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Abstract
Background: Nowadays, moisturizers contain non-steroidal anti-inflammatory agents that help for treatment of atopic dermatitis (AD). Defensil® (black currant seed oil, sunflower oil, and balloon vine), a new anti-inflammatory, obtained from plant extracts, remain had a few studies for AD. Objective: To compare the effectiveness of moisturizer containing 3% Defensil®, 5% dexpanthenol and ceramide (LDC) with 5% urea cream in childhood AD treatment. Methods: Thirty-eight patients with diagnosis of atopic dermatitis by UK working party’s criteria were recruited in randomized, controlled, double-blinded 4-week study. The patients were received with twice-daily application of LDC cream on one side of the body and 5% urea cream on the opposite side. The clinical severity was assessed by modified scoring of atopic dermatitis (SCORAD). Median time to remission was analyzed by survival analysis. Results: Thirty-seven out of 38 patients accomplished the protocol. The clinical SCORAD significantly improved from baseline in both groups (p < 0.001) after 2 and 4 weeks. Furthermore, the LDC group significantly reduced severity of disease better than the 5% urea group (P = 0.043). The mean difference SCORAD scores were-13.83 (±1.83) and-13.04 (±3.22) respectively. Stratum corneum hydration (SCH) was enhanced from baseline in both groups (p < 0.001) but no statistically significant difference between both groups. Median time to remission had no statistically significant difference (P = 0.697). Conclusion: The effectiveness of LDC cream is better than 5% urea cream for improving clinical atopic dermatitis. It was suggested that moisturizer containing LDC could be used for the treatment of mild-to-moderate childhood atopic dermatitis.