Publication: Propargylic-linked [5]helicene derivative for selective Au<sup>3+</sup> detection in near-perfect aqueous media with applications in diverse real samples, paper test strips, and human cells
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Issued Date
2025-03-15
Resource Type
ISSN
13861425
Scopus ID
2-s2.0-85212318032
Pubmed ID
39700548
Journal Title
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume
329
Rights Holder(s)
SCOPUS
Bibliographic Citation
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy Vol.329 (2025)
Suggested Citation
Kaewnok N., Chailek N., Thavornpradit S., Wangngae S., Petdum A., Panchan W., Kamkaew A., Sirirak J., Sooksimuang T., Sanmanee N., Maitarad P., Wanichacheva N. Propargylic-linked [5]helicene derivative for selective Au<sup>3+</sup> detection in near-perfect aqueous media with applications in diverse real samples, paper test strips, and human cells. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy Vol.329 (2025). doi:10.1016/j.saa.2024.125594 Retrieved from: https://hdl.handle.net/20.500.14740/20816
Corresponding Author(s)
Other Contributor(s)
Abstract
Gold is classified as a heavy metal, and its ion (Au3+) can manifest adverse impacts on ecological and human health. Thus, an effective method for Au3+ detection is highly required. In this work, a new [5]helicene-based fluorescence sensor (M202P) was synthesized and applied for Au3+ monitoring in near-perfect aqueous media. M202P rapidly detected Au3+ through a fluorescence quenching response and furnished a large Stokes shift of 157 nm. The Au3+ sensing ability of M202P allowed it to withstand interference from other metal ions, with a detection limit for Au3+ of 8.0 ppb. The mechanism underlying its Au3+ detection was the coordination of Au3+ with the alkyne and carbonyl oxygen, leading to the later hydration of alkynyl moiety, as thoroughly proven by FTIR, 1H NMR, 13C NMR, and HRMS, with the stoichiometric ratio of 1:1 according to Job's plot. In addition, M202P can be used for the quantitative analysis and qualitative fluorescence assay of Au3+ levels in environmental waters and fertilizer solutions. This sensor also demonstrated high potential as a fluorescence tracking agent in human cells and was utilized in fabricating a paper test strip.