Publication:
Pregnancies after Childhood Craniopharyngioma: Results of KRANIOPHARYNGEOM 2000/2007 and Review of the Literature

2
0

Issued Date

2020

Resource Type

Article

File Type

application/pdf

ISSN

283835

DOI

10.1159/000506639

Other identifier(s)

2-s2.0-85098219902

Rights

Srinakharinwirot University

Rights Holder(s)

Scopus

Bibliographic Citation

Neuroendocrinology. Vol 111, (2020), p.16-26

Suggested Citation

Sowithayasakul P., Boekhoff S., Bison B., Müller H.L. Pregnancies after Childhood Craniopharyngioma: Results of KRANIOPHARYNGEOM 2000/2007 and Review of the Literature. Neuroendocrinology. Vol 111, (2020), p.16-26. doi:10.1159/000506639 Retrieved from: https://hdl.handle.net/20.500.14740/5587

Title

Pregnancies after Childhood Craniopharyngioma: Results of KRANIOPHARYNGEOM 2000/2007 and Review of the Literature

Author(s)

Sowithayasakul P.
 Boekhoff S.
 Bison B.
 Müller H.L.

Abstract

Data on female fertility, pregnancy, and outcome of offspring after childhood-onset craniopharyngioma (CP) are rare. Study Design: Observational study on pregnancy rate and offspring outcome in female CP patients recruited in KRANIOPHARYNGEOM 2000/2007 since 2000. Results: A total of 451 CP patients (223 female) have been recruited, and 269 (133 female) were postpubertal at study. Six of 133 female CP patients (4.5%) with a median age of 14.9 years at CP diagnosis had 9 pregnancies, giving birth to 10 newborns. Three patients achieved complete surgical resections. No patient underwent postoperative irradiation. Five natural pregnancies occurred in 3 CP patients without pituitary deficiencies. Four pregnancies in 3 CP patients with hypopituitarism were achieved under assisted reproductive techniques (ART) (median 4.5 cycles, range: 3-6 cycles). Median maternal age at pregnancy was 30 years (range: 22-41 years). Six babies (60%) were delivered by caesarean section. Median gestational age at delivery was 38 weeks (range: 34-43 weeks); median birth weight was 2,920 g (range: 2,270-3,520 g), the rate of preterm delivery was 33%. Enlargements of CP cysts occurred in 2 women during pregnancy. Other complications during pregnancy, delivery, and postnatal period were not observed. Conclusions: Pregnancies after CP are rare and were only achieved after ART in patients with hypopituitarism. Close monitoring by an experienced reproductive physician is necessary. Due to a potentially increased risk for cystic enlargement, clinical, ophthalmological, and MRI monitoring are recommended in patients at risk. Severe perinatal complications, birth defects, and postnatal morbidity of mothers and offspring were not observed. © 2020

Subject(s)

Chorionic gonadotropin
 Desmopressin
 Gonadorelin agonist
 Human menopausal gonadotropin
 Hydrocortisone
 Levothyroxine
 Adolescent
 Adrenal insufficiency
 Adult
 Article
 Birth weight
 Body mass
 Cancer patient
 Cancer radiotherapy
 Cesarean section
 Childhood cancer
 Clinical outcome
 Craniopharyngioma
 Diabetes insipidus
 Fatigue
 Female
 Female fertility
 Gestational age
 Growth rate
 Headache
 Human
 Hypopituitarism
 Hypothyroidism
 Infertility therapy
 Major clinical study
 Male
 Neuroimaging
 Non insulin dependent diabetes mellitus
 Nuclear magnetic resonance imaging
 Observational study
 Ovulation induction
 Perinatal period
 Postoperative care
 Precocious puberty
 Pregnancy
 Pregnancy complication
 Pregnancy rate
 Premature labor
 Prematurity
 Priority journal
 Progeny
 Solid malignant neoplasm
 Tumor volume
 Vaginal delivery
 Young adult

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URI

https://hdl.handle.net/20.500.14740/5587

Collections

Scopus: Year 1983-2021

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