Publication:
Synthesis, in vitro evaluation, and docking studies of novel chromone derivatives as HIV-1 protease inhibitor

0
0

Issued Date

2011

Resource Type

Article

File Type

application/pdf

ISSN

222860

DOI

10.1016/j.molstruc.2011.06.035

Other identifier(s)

2-s2.0-79961032360

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Molecular Structure. Vol 1001, (2011), p.152-161

Suggested Citation

Ungwitayatorn J., Wiwat C., Samee W., Nunthanavanit P., Phosrithong N. Synthesis, in vitro evaluation, and docking studies of novel chromone derivatives as HIV-1 protease inhibitor. Journal of Molecular Structure. Vol 1001, (2011), p.152-161. doi:10.1016/j.molstruc.2011.06.035 Retrieved from: https://hdl.handle.net/20.500.14740/7258

Title

Synthesis, in vitro evaluation, and docking studies of novel chromone derivatives as HIV-1 protease inhibitor

Author(s)

Ungwitayatorn J.
 Wiwat C.
 Samee W.
 Nunthanavanit P.
 Phosrithong N.

Abstract

Novel chromone derivatives with a benzopyran-4-one scaffold have been prepared by the one-pot cyclization reaction. The in vitro inhibitory activity of these new compounds towards HIV-1 protease have been evaluated using stop time HPLC method as the preliminary screening. The most potent compound, 7,8-dihydroxy-2-(3′-trifluoromethyl phenyl)-3-(3″- trifluoromethylbenzoyl)chromone (32), showed IC50 = 0.34 μM. The molecular docking study supported results from experimental activity testing and also provided structure-activity relationship of this series. © 2011 Elsevier B.V. All rights reserved.

Subject(s)

Chromone derivatives
 Chromones
 Cyclization reactions
 HIV-1 protease
 HIV-1 protease inhibitors
 HPLC method
 In-vitro
 In-vitro evaluation
 Inhibitory activity
 Molecular docking
 One pot
 Potent compounds
 Structure activity relationships
 Trifluoromethyl
 Cyclization
 Molecular modeling
 Scaffolds
 Synthesis (chemical)
 Docking
 Human immunodeficiency virus
 Human immunodeficiency virus 1

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/7258

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By