Publication:
Treatment of laryngopharyngeal reflux: A comparison between domperidone plus omeprazole and omeprazole alone

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Issued Date

2012

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-84856940056

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 95, No.1 (2012), p.73-80

Suggested Citation

Hunchaisri N. Treatment of laryngopharyngeal reflux: A comparison between domperidone plus omeprazole and omeprazole alone. Journal of the Medical Association of Thailand. Vol 95, No.1 (2012), p.73-80. Retrieved from: https://hdl.handle.net/20.500.14740/7142

Title

Treatment of laryngopharyngeal reflux: A comparison between domperidone plus omeprazole and omeprazole alone

Author(s)

Hunchaisri N.

Abstract

Objective: To evaluate the efficacy of domperidone in combination with omeprazole in the treatment of laryngopharyngeal reflux (LPR) compare to omeprazole alone. Material and Method: A prospective and randomized study included seventy patients with a reflux symptom index (RSI) 13 or more. They received either domperidone 10 mg thrice daily plus omeprazole 20 mg twice daily or omeprazole alone for three months. RSI was assessed at baseline and after three months of treatment. Results: Total RSI as well as several subscores were comparable between groups before the treatment. After three months of the treatment, moderate improvement of total RSI was shown in both groups (72.7%, 67.5%). The reduction of total RSI and individual subscores were statistically significant within each group (p < 0.001 each). Comparing between each treatment group, the mean difference of total RSI and individual subscores did not shown any statistically differences (p > 0.05 each) at the end of the study period. Conclusion: Domperidone in combination with omeprazole is not superior to omeprazole alone in the treatment of LPR.

Subject(s)

Domperidone
 Omeprazole
 Adult
 Aged
 Article
 Clinical article
 Combination chemotherapy
 Comparative study
 Controlled study
 Drug efficacy
 Drug response
 Female
 Human
 Laryngopharyngeal reflux
 Male
 Monotherapy
 Outcome assessment
 Prospective study
 Randomized controlled trial
 Reflux symptom index
 Scoring system
 Sex difference
 Anti-Ulcer Agents
 Chi-Square Distribution
 Domperidone
 Dopamine Antagonists
 Drug Therapy, Combination
 Female
 Humans
 Laryngopharyngeal Reflux
 Male
 Middle Aged
 Omeprazole
 Prospective Studies
 Treatment Outcome

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URI

https://hdl.handle.net/20.500.14740/7142

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Scopus: Year 1983-2021

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