Publication: Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment
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Issued Date
2021
Resource Type
Language
eng
File Type
application/pdf
ISSN
20452322
Other identifier(s)
2-s2.0-85121450526
Rights Holder(s)
Scopus
Bibliographic Citation
Scientific Reports. Vol 11, No.1 (2021)
Suggested Citation
Sawutdeechaikul P., Kanokrungsee S., Sahaspot T., Thadvibun K., Banlunara W., Limcharoen B., Sansureerungsikul T., Rutwaree T., Oungeun M., Wanichwecharungruang S. Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment. Scientific Reports. Vol 11, No.1 (2021). doi:10.1038/s41598-021-03503-5 Retrieved from: https://hdl.handle.net/20.500.14740/4188
Abstract
Delivering bioactive compounds into skin tissue has long been a challenge. Using ex vivo porcine and rat skins, here we demonstrate that a detachable dissolvable microneedle (DDMN) array, a special dissolvable microneedle that allows needle detachment from the base within 2 min post administration, can effectively embed a model compound into epidermis and dermis. Diffusion of the compound from the needle embedding sites to the nearby skin tissue is demonstrated at various post administration periods. The relationship between the time that a conventional dissolvable microneedle array is left on skin without needle detachment from the base and the degree of skin surface abrasion at each microneedle penetration spot is also demonstrated on skin of human volunteers. Co-loading glutathione with vitamin C (vitC) can stabilize vitC in the DDMN. DDMN loaded with vitC and glutathione can help erasing post-acne-hyperpigmentation spots. © 2021, The Author(s).
Subject(s)
Ascorbic acid
Glutathione
Animal
Diffusion
Drug delivery system
Drug stability
Epidermis
Functions of the skin and its appendages
Human
Hyperpigmentation
Intradermal drug administration
Metabolism
Microinjection
Needle
Pig
Procedures
Rat
Animals
Ascorbic Acid
Diffusion
Drug Delivery Systems
Drug Stability
Epidermis
Glutathione
Humans
Hyperpigmentation
Injections, Intradermal
Microinjections
Needles
Rats
Skin Physiological Phenomena
Swine
Glutathione
Animal
Diffusion
Drug delivery system
Drug stability
Epidermis
Functions of the skin and its appendages
Human
Hyperpigmentation
Intradermal drug administration
Metabolism
Microinjection
Needle
Pig
Procedures
Rat
Animals
Ascorbic Acid
Diffusion
Drug Delivery Systems
Drug Stability
Epidermis
Glutathione
Humans
Hyperpigmentation
Injections, Intradermal
Microinjections
Needles
Rats
Skin Physiological Phenomena
Swine