Publication: Anti-inflammatory, anti-bacterial and anti-acetylcholinesterase activities of two isoquinoline alkaloids-scoulerine and cheilanthifoline
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Issued Date
2016
Resource Type
File Type
application/pdf
ISSN
1934578X
Other identifier(s)
2-s2.0-85019168794
Rights Holder(s)
Scopus
Bibliographic Citation
Natural Product Communications. Vol 11, No.12 (2016), p.1801-1804
Suggested Citation
Wangchuk P., Sastraruji T., Taweechotipatr M., Keller P.A., Pyne S.G. Anti-inflammatory, anti-bacterial and anti-acetylcholinesterase activities of two isoquinoline alkaloids-scoulerine and cheilanthifoline. Natural Product Communications. Vol 11, No.12 (2016), p.1801-1804. doi:10.1177/1934578x1601101207 Retrieved from: https://hdl.handle.net/20.500.14740/4928
Abstract
Corydalis plants containing isoquinoline alkaloids are reported to possess promising pharmacological properties for the treatment of important diseases including cancer, inflammation, Alzheimer's disease and microbial infections. As part of a wider program investigating Bhutanese medicinal plants, we have previously identified eight isoquinoline alkaloids from C. dubia. Out of these, we report here on two of the major alkaloids, scoulerine (1) and cheilanthifoline (2) and their inhibitory activities against acetylcholinesterase (anti-AChE), tumor necrosis factor alpha (anti TNF-α) and a bacterial strain, Helicobacter pylori. Both alkaloids showed weak anti TNF-α and antibacterial activities. However, the anti-AChE activity of scoulerine (1) was promising as it significantly inhibited AChE with a minimum inhibitory requirement (MIR) value of 0.0015 nmol, which was two-fold better than the reference drug, galanthamine (MIR value of 0.003 nmol). As there are limited anti-Alzheimer's chemotherapeutics, scoulerine (1) is worthy of further exploration, including lead optimization, structure-activity-relationship studies, analog development, pharmacodynamics and in vivo animal studies.
Subject(s)
Amoxicillin
Amphotericin B
Cheilanthifoline
Dexamethasone
Galantamine
Isoquinoline alkaloid
Scoulerine
Tumor necrosis factor
Unclassified drug
Vancomycin
Acetylcholinesterase activity
Antibacterial activity
Antiinflammatory activity
Article
Bacterial strain
Controlled study
Drug activity
Drug structure
Helicobacter pylori
Minimum inhibitory concentration
Nonhuman
Amphotericin B
Cheilanthifoline
Dexamethasone
Galantamine
Isoquinoline alkaloid
Scoulerine
Tumor necrosis factor
Unclassified drug
Vancomycin
Acetylcholinesterase activity
Antibacterial activity
Antiinflammatory activity
Article
Bacterial strain
Controlled study
Drug activity
Drug structure
Helicobacter pylori
Minimum inhibitory concentration
Nonhuman