Publication:
Astraodoric acids A-D: New lanostane triterpenes from edible mushroom astraeus odoratus and their anti-mycobacterium tuberculosis H37Ra and cytotoxic activity

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Issued Date

2012

Resource Type

Article

File Type

application/pdf

ISSN

218561

DOI

10.1021/jf302433r

Other identifier(s)

2-s2.0-84867075044

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of Agricultural and Food Chemistry. Vol 60, No.39 (2012), p.9834-9841

Suggested Citation

Arpha K., Phosri C., Suwannasai N., Mongkolthanaruk W., Sodngam S. Astraodoric acids A-D: New lanostane triterpenes from edible mushroom astraeus odoratus and their anti-mycobacterium tuberculosis H37Ra and cytotoxic activity. Journal of Agricultural and Food Chemistry. Vol 60, No.39 (2012), p.9834-9841. doi:10.1021/jf302433r Retrieved from: https://hdl.handle.net/20.500.14740/6948

Title

Astraodoric acids A-D: New lanostane triterpenes from edible mushroom astraeus odoratus and their anti-mycobacterium tuberculosis H37Ra and cytotoxic activity

Author(s)

Arpha K.
 Phosri C.
 Suwannasai N.
 Mongkolthanaruk W.
 Sodngam S.

Abstract

Tuberculosis (TB) is one of the chronic infectious diseases caused by Mycobacterium tuberculosis that causes about 2-3 million deaths per year. Isoniazid and rifampicin are examples of first line drugs used for TB treatment; however, they are potentially hepatotoxic. More effective and safer drugs are urgently needed, especially from natural products. Basidiomycete mushrooms are known as important sources of pharmaceutically active metabolites including an anti-TB agent. In this work, the chemical constituents of the edible mushroom Astraeus odoratus were isolated and investigated for antibacterial activity against M. tuberculosis H37Ra. The cytotoxic activity against cancerous cell lines was also evaluated. Four new lanostane triterpenes, astraodoric acids A-D, and new 5-hydroxyhypaphorine have been isolated together with four known compounds. The structures were elucidated by NMR spectroscopic methods, HR-ESI-MS results, and X-ray crystallographic analysis. Astraodoric acids A and B exhibited moderate antibacterial (MICs of 50 and 25 μg/mL) and cytotoxic activities (IC50 values of 34.69 and 18.57 μg/mL against KB and 19.99 and 48.35 μg/mL against NCI-H187), respectively. The results of this study show that A. odoratus could be a significant natural source for safer antitubercular and anticancer agents. © 2012 American Chemical Society.

Subject(s)

Antituberculosis
 Astraeus odoratus
 Astraodoric acids A-D
 Cytotoxic activities
 Hypaphorine
 Triterpenes
 Cell culture
 Cytotoxicity
 Fungi
 Spectroscopic analysis
 X ray crystallography
 Tubes (components)
 Triterpene
 Tuberculostatic agent
 Agaricales
 Article
 Cell survival
 Chemistry
 Drug effect
 Human
 Isolation and purification
 Microbial sensitivity test
 Microbiology
 Mycobacterium tuberculosis
 Tuberculosis
 Tumor cell line
 Agaricales
 Antitubercular Agents
 Cell Line, Tumor
 Cell Survival
 Humans
 Microbial Sensitivity Tests
 Mycobacterium tuberculosis
 Triterpenes
 Tuberculosis
 Astraeus odoratus
 Basidiomycota
 Mycobacterium tuberculosis

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URI

https://hdl.handle.net/20.500.14740/6948

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Scopus: Year 1983-2021

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