Publication:
Potential role of royal jelly and 10-hydroxy-2-decenoic acid as metastasis inhibitors in triple-negative breast cancer cells

1
0

Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-85070254772

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 102, No.7 (2019), p.17-24

Suggested Citation

Pengpanich S., Srisuparbh D., Uthaisang-Tanechpongtamb W. Potential role of royal jelly and 10-hydroxy-2-decenoic acid as metastasis inhibitors in triple-negative breast cancer cells. Journal of the Medical Association of Thailand. Vol 102, No.7 (2019), p.17-24. Retrieved from: https://hdl.handle.net/20.500.14740/5278

Title

Potential role of royal jelly and 10-hydroxy-2-decenoic acid as metastasis inhibitors in triple-negative breast cancer cells

Author(s)

Pengpanich S.
 Srisuparbh D.
 Uthaisang-Tanechpongtamb W.

Abstract

Background: Royal jelly (RJ) produced by honeybees has been reported to possess various pharmacological activities. For the role of antitumor, RJ has been demonstrated in several types of cancer cells which 10-hydroxy-2-decenoic acid (10-HDA) proposed as an active component. In the present study, the authors aimed to expand more knowledge of the antitumor effect of RJ and 10-HDA in the aspect of metastasis inhibition. Triple negative breast cancer cells (TNBC) that are often aggressive and associated with poor prognosis were selected as a model for the present study. Materials and Methods: An MTT assay was used for determination of cytotoxicity, while migration, invasion and adhesion assays were used to evaluate metastatic potential. The effect of angiogenesis was assessed by the level of pro-angiogenic factor, VEGF. Results: RJ decreased the cell viability of TNBC (MDA-MB-231) cells and other cancer cells (Colo205, HepG2, HeLa and KB). The blockage of TNBC migration was clearly seen when the cells were treated with RJ or 10-HDA. The invasion, adhesion and release of VEGF were significantly inhibited by 10-HDA. Conclusion: RJ and 10-HDA have potential of anti-metastatic activity against aggressive breast cancer cells. © Journal Of The Medical Association Of Thailand| 2019.

Subject(s)

10 hydroxy 2 decenoic acid
 Angiogenic factor
 Antimetastatic agent
 Royal jelly
 Vasculotropin
 Angiogenesis
 Article
 Cell adhesion
 Cell invasion
 Cell migration
 Cell viability
 COLO 205 cell line
 Controlled study
 Cytotoxicity
 HeLa cell line
 Hep-G2 cell line
 Human
 Human cell
 KB cell line
 MDA-MB-231 cell line
 Metastasis
 Metastasis inhibition
 Metastasis potential
 MTT assay
 Protein secretion
 Triple negative breast cancer

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/5278

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By