Publication: Novel activities of 1-Adamantylthiopyridines as antibacterials, antimalarials and anticancers
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Issued Date
2009
Resource Type
File Type
application/pdf
ISSN
16112156
Other identifier(s)
2-s2.0-70349916584
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
EXCLI Journal. Vol 8, No. (2009), p.121-129
Suggested Citation
Prachayasittikul S., Treeratanapiboon L., Ruchirawat S., Prachayasittikul V. Novel activities of 1-Adamantylthiopyridines as antibacterials, antimalarials and anticancers. EXCLI Journal. Vol 8, No. (2009), p.121-129. Retrieved from: https://hdl.handle.net/20.500.14740/6292
Abstract
To discover new bioactive lead compounds for medicinal purposes, herein, 2(1-adamantylthio)pyridine and derivatives (1-10) were prepared and tested for antibacterial (agar dilution method against 27 strains of microorganisms), antimalarial (against Plasmodium falciparum) and anticancer (MOLT-3, HepG2, HuCCA-1 and A549) activities. Results showed that all the tested derivatives selectively exerted antigrowth activity against Streptococci at 15-30 μg/mL. 3-Substituted (R) thiopyridines; 3 (R = NAc2), 5 (R = OH) and 6 (R = Br) exhibited antibacterials, antimalarials and anticancers. Significantly, 6-(1-adamantylthio) nicotinonitrile (10) is a promising antibacterial which selectively displays antigrowth activity against Vibrio cholerae, Vibrio parahaemolyticus, Edwardsiella tarda and β-hemolytic Streptococcus group A with minimum inhibitory concentration of 30 μg/mL. The findings reveal that these 1-adamantylthiopyridines represent a novel class of antibacterial, antimalarial and anticancer agents with potential medicinal values.